FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984420230> ?p ?o ?g. }

• W1984420230 endingPage "4905" @default.
• W1984420230 startingPage "4896" @default.
• W1984420230 abstract "We tested a hypothesis that the spinal plasticity induced within a few hours after nerve injury may produce changes in cortical activities and an initial phase of neuropathic pain. Somatosensory cortical responses elicited by vibratory stimulation were visualized by transcranial flavoprotein fluorescence imaging in mice. These responses were reduced immediately after cutting the sensory nerves. However, the remaining cortical responses mediated by nearby nerves were potentiated within a few hours after nerve cutting. Nerve injury induces neuropathic pain. In the present study, mice exhibited tactile allodynia 1–2 weeks after nerve injury. Lesioning of the ipsilateral dorsal column, mediating tactile cortical responses, abolished somatic cortical responses to tactile stimuli. However, nontactile cortical responses appeared in response to the same tactile stimuli within a few hours after nerve injury, indicating that tactile allodynia was acutely initiated. We investigated the trigger mechanisms underlying the cortical changes. Endogenous glial cell line-derived neurotrophic factor (GDNF), found in the Meissner corpuscles, induced basal firing ∼0.1 Hz or less in its Aβ tactile afferents, and disruption of the basal firing triggered the potentiation of nontactile cortical responses. Application of 10 n m LY341495 [(2 S )-2-amino-2-[(1 S ,2 S )-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid], a specific antagonist of group II metabotropic glutamate receptors (mGluRs), on to the surface of the spinal cord also induced the potentiation of nontactile cortical responses. Together, it is suggested that low-frequency afferent firing produced by GDNF in touch-sensitive nerve fibers continuously activated spinal group II mGluRs and that failure of this activation triggered tactile allodynia." @default.
• W1984420230 created "2016-06-24" @default.
• W1984420230 creator A5024840673 @default.
• W1984420230 creator A5035228067 @default.
• W1984420230 creator A5036177715 @default.
• W1984420230 creator A5040214197 @default.
• W1984420230 creator A5054638866 @default.
• W1984420230 creator A5065124090 @default.
• W1984420230 creator A5070100086 @default.
• W1984420230 creator A5078560173 @default.
• W1984420230 date "2011-03-30" @default.
• W1984420230 modified "2023-09-26" @default.
• W1984420230 title "Initial Phase of Neuropathic Pain within a Few Hours after Nerve Injury in Mice" @default.
• W1984420230 cites W123790764 @default.
• W1984420230 cites W1538992523 @default.
• W1984420230 cites W1568486516 @default.
• W1984420230 cites W1623378741 @default.
• W1984420230 cites W1625740378 @default.
• W1984420230 cites W1793614400 @default.
• W1984420230 cites W1959152155 @default.
• W1984420230 cites W1963806203 @default.
• W1984420230 cites W1965866432 @default.
• W1984420230 cites W1969580888 @default.
• W1984420230 cites W1970812448 @default.
• W1984420230 cites W1971121537 @default.
• W1984420230 cites W1974527199 @default.
• W1984420230 cites W1974813892 @default.
• W1984420230 cites W1975768945 @default.
• W1984420230 cites W1977644846 @default.
• W1984420230 cites W1978269241 @default.
• W1984420230 cites W1981420931 @default.
• W1984420230 cites W1981854032 @default.
• W1984420230 cites W1982095811 @default.
• W1984420230 cites W1984025105 @default.
• W1984420230 cites W1992857164 @default.
• W1984420230 cites W2014779151 @default.
• W1984420230 cites W2020348231 @default.
• W1984420230 cites W2025011441 @default.
• W1984420230 cites W2027635015 @default.
• W1984420230 cites W2036790170 @default.
• W1984420230 cites W2037667533 @default.
• W1984420230 cites W2038793161 @default.
• W1984420230 cites W2040200937 @default.
• W1984420230 cites W2041810846 @default.
• W1984420230 cites W2047010161 @default.
• W1984420230 cites W2048516550 @default.
• W1984420230 cites W2048968739 @default.
• W1984420230 cites W2053695679 @default.
• W1984420230 cites W2058020736 @default.
• W1984420230 cites W2064908968 @default.
• W1984420230 cites W2065750611 @default.
• W1984420230 cites W2066796908 @default.
• W1984420230 cites W2067924690 @default.
• W1984420230 cites W2071595010 @default.
• W1984420230 cites W2082506941 @default.
• W1984420230 cites W2085283029 @default.
• W1984420230 cites W2092079460 @default.
• W1984420230 cites W2092595668 @default.
• W1984420230 cites W2094381755 @default.
• W1984420230 cites W2103671483 @default.
• W1984420230 cites W2142996110 @default.
• W1984420230 cites W2145771801 @default.
• W1984420230 cites W2146840152 @default.
• W1984420230 cites W2158602841 @default.
• W1984420230 cites W2166710158 @default.
• W1984420230 cites W2265283614 @default.
• W1984420230 cites W2409766273 @default.
• W1984420230 doi "https://doi.org/10.1523/jneurosci.6753-10.2011" @default.
• W1984420230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6623000" @default.
• W1984420230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21451028" @default.
• W1984420230 hasPublicationYear "2011" @default.
• W1984420230 type Work @default.
• W1984420230 sameAs 1984420230 @default.
• W1984420230 citedByCount "23" @default.
• W1984420230 countsByYear W19844202302012 @default.
• W1984420230 countsByYear W19844202302013 @default.
• W1984420230 countsByYear W19844202302014 @default.
• W1984420230 countsByYear W19844202302015 @default.
• W1984420230 countsByYear W19844202302016 @default.
• W1984420230 countsByYear W19844202302018 @default.
• W1984420230 countsByYear W19844202302019 @default.
• W1984420230 countsByYear W19844202302020 @default.
• W1984420230 countsByYear W19844202302021 @default.
• W1984420230 countsByYear W19844202302022 @default.
• W1984420230 countsByYear W19844202302023 @default.
• W1984420230 crossrefType "journal-article" @default.
• W1984420230 hasAuthorship W1984420230A5024840673 @default.
• W1984420230 hasAuthorship W1984420230A5035228067 @default.
• W1984420230 hasAuthorship W1984420230A5036177715 @default.
• W1984420230 hasAuthorship W1984420230A5040214197 @default.
• W1984420230 hasAuthorship W1984420230A5054638866 @default.
• W1984420230 hasAuthorship W1984420230A5065124090 @default.
• W1984420230 hasAuthorship W1984420230A5070100086 @default.
• W1984420230 hasAuthorship W1984420230A5078560173 @default.
• W1984420230 hasBestOaLocation W19844202301 @default.
• W1984420230 hasConcept C126322002 @default.
• W1984420230 hasConcept C15490471 @default.
• W1984420230 hasConcept C15744967 @default.

• next