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- W1984421787 abstract "Our earlier studies have shown that Kir2 channels are strongly suppressed by the elevation of cellular cholesterol and enhanced by cholesterol depletion. We have also shown that Kir2 channels partially partition into cholesterol-rich membrane domains suggesting that interactions between the channels and other components of these domains may be critical for the regulation of the channels. It is also known that cholesterol interacts with caveolin-1, a scaffolding regulatory protein residing in these domains. In this study we test whether Kir2 channels are regulated by caveolin under different cholesterol conditions. Our data shows that Cav-1 co-immunoprecipitates with both Kir2.1 and Kir2.3 channels, suggesting that Cav -1 may be involved in the regulation of Kir2 channels. Furthermore, we show here that bone-marrow derived macrophages isolated from Cav−/− knock-out mice have larger Kir currents than cells isolated from control animals supporting the hypothesis that Cav-1 regulates Kir channels. Finally, we also show that sensitivity of Kir currents to cholesterol in Cav−/− cells is weaker than in control cells providing further evidence for the role of Cav-1 in the sensitivity of Kir channels to cholesterol." @default.
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- W1984421787 date "2009-02-01" @default.
- W1984421787 modified "2023-09-28" @default.
- W1984421787 title "Role of Kir 2-caveolin-1 interactions in the sensitivity of Kir to cholesterol" @default.
- W1984421787 doi "https://doi.org/10.1016/j.bpj.2008.12.2380" @default.
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