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- W1984433058 abstract "We investigated the regulatory influence of several cytokines on the expression of preproenkephalin (PPE) mRNA in human peripheral blood mononuclear cells (PBMC). By use of a quantitative reverse-transcriptase-polymerase chain reaction (RT-PCR), we demonstrate that the T helper 2 cytokines IL-4 and IL-10 are more potent in upregulating PPE mRNA expression in human PBMC than the T helper 1 cytokines IL-2 and γ-IFN. In addition, TGF-β is also an effective inducer of PPE mRNA. TGF-β, IL-4 and IL-10 increase the cytoplasmatic concentration of met-enkephalin in PBMC. Secretion of met-enkephalin in the culture supernatant of IL-4- or IL-10-stimulated PBMC could not be observed, but proenkephalin A-derived met-enkephalin containing peptides could be demonstrated. IL-4 and IL-10 do not induce PPE mRNA via the same pathways. We could observe that PKA is involved in IL-4 mediated PPE mRNA induction, whereas IL-10 apparently uses another route." @default.
- W1984433058 created "2016-06-24" @default.
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- W1984433058 date "1997-10-01" @default.
- W1984433058 modified "2023-09-27" @default.
- W1984433058 title "T helper 2 cytokines induce preproenkephalin mRNA expression and proenkephalin A in human peripheral blood mononuclear cells" @default.
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- W1984433058 doi "https://doi.org/10.1016/s0165-5728(97)00113-6" @default.
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