FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984464192> ?p ?o ?g. }

• W1984464192 endingPage "109" @default.
• W1984464192 startingPage "101" @default.
• W1984464192 abstract "In this study, a comparative evaluation between a Salmonella ghost vaccine expressing enterotoxigenic Escherichia coli (ETEC) fimbrial antigens and a commercial ETEC vaccine was conducted in neonatal piglets. Genes encoding the ETEC K88ab, K88ac, K99, FasA, and F41 fimbrial proteins were individually cloned into an expression/ghost plasmid (pJHLP184) carrying the pBR origin, asd, the ompA signal sequence to direct antigens to the cell membrane, cI857/λPR promoter, araC ParaBAD, and the phiX174 lysis gene E. Individual clones were subsequently used to electroporate a Δasd S. Typhimurium strain, and positive clones were used to generate Salmonella ghosts. Pregnant sows (n=12) were equally divided into four groups. Pregnant sows were primed and boosted at 11 and 14 weeks of pregnancy, respectively. Group A, B, and C sows were intramuscularly inoculated with PBS as a control, a commercial vaccine, and with 2×10(10) ghost cells, respectively, while group D sows were orally immunized with 2×10(10) ghost cells. All the vaccinated sows and their offspring exhibited increased ETEC fimbrial antigen antibody levels relative to those in the unimmunized group A. Especially, serum IgG and colostrum IgA levels in the group D sows and serum IgG and IgA levels in their piglets were significantly higher than those in control group sows and offspring, respectively. The levels of interleukin-4 against all the fimbrial proteins in peripheral blood lymphocytes of group D sows also increased significantly, whereas no difference between the control group and any of the immunized groups was detected for interferon-γ. In addition, the piglets of group D did not experience diarrhea following challenge with virulent ETEC strains. Diarrhea was observed in 88.9%, 30.4%, and 23.5% of the piglets in groups A, B and C, respectively. Mortality was observed in 16.7% and 5.9% of the piglets in groups A and C, respectively. These findings indicate that immunization of sows with the ghost vaccine candidate, especially by the oral route, can effectively protect their offspring against E. coli colibacillosis." @default.
• W1984464192 created "2016-06-24" @default.
• W1984464192 creator A5015511808 @default.
• W1984464192 creator A5040395780 @default.
• W1984464192 date "2015-04-01" @default.
• W1984464192 modified "2023-09-27" @default.
• W1984464192 title "A new enterotoxigenic Escherichia coli vaccine candidate constructed using a Salmonella ghost delivery system: Comparative evaluation with a commercial vaccine for neonatal piglet colibacillosis" @default.
• W1984464192 cites W1965182769 @default.
• W1984464192 cites W1975627723 @default.
• W1984464192 cites W1995993192 @default.
• W1984464192 cites W1997332169 @default.
• W1984464192 cites W1999343841 @default.
• W1984464192 cites W2001285947 @default.
• W1984464192 cites W2009346366 @default.
• W1984464192 cites W2010778887 @default.
• W1984464192 cites W2010996659 @default.
• W1984464192 cites W2011185726 @default.
• W1984464192 cites W2022564080 @default.
• W1984464192 cites W2023399474 @default.
• W1984464192 cites W2024482397 @default.
• W1984464192 cites W2031003734 @default.
• W1984464192 cites W2034005306 @default.
• W1984464192 cites W2041184747 @default.
• W1984464192 cites W2043124445 @default.
• W1984464192 cites W2044970691 @default.
• W1984464192 cites W2056434119 @default.
• W1984464192 cites W2058611031 @default.
• W1984464192 cites W2065897793 @default.
• W1984464192 cites W2070115760 @default.
• W1984464192 cites W2070668351 @default.
• W1984464192 cites W2072682408 @default.
• W1984464192 cites W2074141045 @default.
• W1984464192 cites W2080907624 @default.
• W1984464192 cites W2081737419 @default.
• W1984464192 cites W2083986955 @default.
• W1984464192 cites W2085087038 @default.
• W1984464192 cites W2092369966 @default.
• W1984464192 cites W2092938807 @default.
• W1984464192 cites W2095314541 @default.
• W1984464192 cites W2103080556 @default.
• W1984464192 cites W2104221229 @default.
• W1984464192 cites W2108491614 @default.
• W1984464192 cites W2112111992 @default.
• W1984464192 cites W2119165723 @default.
• W1984464192 cites W2122931405 @default.
• W1984464192 cites W2128953086 @default.
• W1984464192 cites W2135929283 @default.
• W1984464192 cites W2144137216 @default.
• W1984464192 cites W2144590107 @default.
• W1984464192 cites W2145336455 @default.
• W1984464192 cites W2147285474 @default.
• W1984464192 cites W2157222029 @default.
• W1984464192 cites W2166180052 @default.
• W1984464192 cites W2169242217 @default.
• W1984464192 cites W2319594759 @default.
• W1984464192 doi "https://doi.org/10.1016/j.vetimm.2015.01.010" @default.
• W1984464192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25712756" @default.
• W1984464192 hasPublicationYear "2015" @default.
• W1984464192 type Work @default.
• W1984464192 sameAs 1984464192 @default.
• W1984464192 citedByCount "14" @default.
• W1984464192 countsByYear W19844641922016 @default.
• W1984464192 countsByYear W19844641922017 @default.
• W1984464192 countsByYear W19844641922018 @default.
• W1984464192 countsByYear W19844641922020 @default.
• W1984464192 crossrefType "journal-article" @default.
• W1984464192 hasAuthorship W1984464192A5015511808 @default.
• W1984464192 hasAuthorship W1984464192A5040395780 @default.
• W1984464192 hasConcept C104317684 @default.
• W1984464192 hasConcept C112672928 @default.
• W1984464192 hasConcept C147483822 @default.
• W1984464192 hasConcept C159047783 @default.
• W1984464192 hasConcept C159654299 @default.
• W1984464192 hasConcept C203014093 @default.
• W1984464192 hasConcept C22744801 @default.
• W1984464192 hasConcept C2777871010 @default.
• W1984464192 hasConcept C2779073587 @default.
• W1984464192 hasConcept C2779234561 @default.
• W1984464192 hasConcept C2781065037 @default.
• W1984464192 hasConcept C523546767 @default.
• W1984464192 hasConcept C54355233 @default.
• W1984464192 hasConcept C547475151 @default.
• W1984464192 hasConcept C66999527 @default.
• W1984464192 hasConcept C86803240 @default.
• W1984464192 hasConcept C89423630 @default.
• W1984464192 hasConceptScore W1984464192C104317684 @default.
• W1984464192 hasConceptScore W1984464192C112672928 @default.
• W1984464192 hasConceptScore W1984464192C147483822 @default.
• W1984464192 hasConceptScore W1984464192C159047783 @default.
• W1984464192 hasConceptScore W1984464192C159654299 @default.
• W1984464192 hasConceptScore W1984464192C203014093 @default.
• W1984464192 hasConceptScore W1984464192C22744801 @default.
• W1984464192 hasConceptScore W1984464192C2777871010 @default.
• W1984464192 hasConceptScore W1984464192C2779073587 @default.
• W1984464192 hasConceptScore W1984464192C2779234561 @default.
• W1984464192 hasConceptScore W1984464192C2781065037 @default.
• W1984464192 hasConceptScore W1984464192C523546767 @default.
• W1984464192 hasConceptScore W1984464192C54355233 @default.

• next