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- W1984465816 abstract "A recent study that analyzed results from 15 genome wide association studies (GWAS) for body mass index (BMI) identified eight single nucleotide polymorphisms (SNPs) associated with BMI in an older population (43-68 yrs) and suggested that the development of obesity has a significant central nervous system (CNS) component. PURPOSE: We set out to examine whether these 8 SNPs would also be associated with measures of BMI and subcutaneous fat in a young, college-aged population, and whether these SNPs would influence the response of these variables to a resistance training program. METHODS: We genotyped the following 8 SNPs: NEGR1 (rs2815752), MTCH2 (rs10838738), TMEM18 (rs6548238), GNPDA2 (rs10938397), SH2B1 (rs7498665), MCR4 (rs17782313), FTO (rs9939609), and KCTD15 (rs11084753) in a cohort of young, healthy individuals (mean age = 24yr). The individuals in our cohort then participated in a 12-week resistance-training program targeting the upper arm muscles. Genotype/phenotype associations for BMI and subcutaneous fat before and after the exercise program were tested using an analysis of covariance model with age and weight as covariates. Additionally, the percent variation in each phenotype attributable to genotype was determined using hierarchical models with a likelihood ratio test. RESULTS: Females with a copy of the rare allele (C) for rs17782313 had significantly higher BMI values (CC/CT: n=174; 24.70 ± 0.33 kg/m2, TT; n=278; 23.41 ± 0.26, p=0.0025). Men with a copy of the rare allele (A) for rs9939609 lost a significant amount of subcutaneous fat with exercise (AT/AA; n=83; -798.35 ± 2624.30, TT; n=47; 9435.23 ± 3494.44, p=0.0190). We did not observe any effect of the other six SNPs with baseline subcutaneous fat, BMI, or change in BMI/subcutaneous fat with resistance training. CONCLUSIONS: This data supports and extends the original findings by showing a similar association between a MC4R variant and BMI in a younger population. Additionally, this study adds to the previous data by showing that a FTO variant may affect the response of subcutaneous fat to exercise in addition to influencing baseline BMI." @default.
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- W1984465816 date "2010-05-01" @default.
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- W1984465816 title "Polymorphisms From GWAS Studies Are Associated With BMI and Post-Exercise Fat Loss In College Students" @default.
- W1984465816 doi "https://doi.org/10.1249/01.mss.0000386466.93266.59" @default.
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