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• W1984465891 abstract "The circadian clock mechanism in mammals involves two interlocking transcriptional feedback loops. Rev-erb α, through its role as a transcriptional repressor, was thought to be the primary determinant of the feedback loop that regulates Bmal1 transcription. Results reported by Sato et al. in this issue of Neuron now show that the transactivator Rora acts coordinately with Rev-erb α and that their competing activities on the same promoter element drive the rhythm in Bmal1 transcription. This finding defines the second feedback loop in mammals." @default.
• W1984465891 created "2016-06-24" @default.
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• W1984465891 date "2004-08-01" @default.
• W1984465891 modified "2023-10-02" @default.
• W1984465891 title "A Rhythmic Ror" @default.
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• W1984465891 doi "https://doi.org/10.1016/j.neuron.2004.08.009" @default.
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