Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984467110> ?p ?o ?g. }
- W1984467110 endingPage "1710" @default.
- W1984467110 startingPage "1702" @default.
- W1984467110 abstract "Objective: In Spring 2011, an unprecedented outbreak of Shiga toxin–producing Escherichia coli serotype O104:H4–associated hemolytic uremic syndrome occurred in Northern Germany. The aim of this study was to describe the clinical characteristics, treatments, and outcomes of critically ill patients with Shiga toxin–producing E. coli–associated hemolytic uremic syndrome during this outbreak. Design, Setting, and Patients: Multicenter, retrospective, observational study of critically ill adult patients with Shiga toxin–producing E. coli–associated hemolytic uremic syndrome in six hospitals in Hamburg, Germany, between May 2011 and August 2011. Measurements and Main Results: During the study period, 106 patients with Shiga toxin–producing E. coli–associated hemolytic uremic syndrome were admitted to eight ICUs. The median age was 40 years (range, 18–83) with a female:male ratio of 3:1. The median time from onset of clinical symptoms to hospital admission was 3 days and from hospital to ICU admission an additional 3 days. A total of 101 patients (95.3%) had acute renal failure and 78 (73.6%) required renal replacement therapy. Intubation and mechanical ventilation were required in 38 patients (35.8%) and noninvasive ventilation was required in 17 patients (16.0%). The median duration of invasive ventilation was 7 days (range, 1–32 days) and the median ICU stay was 10 days (range, 1–45 days). Fifty-one patients (48.1%) developed sepsis; of these 51 patients, 27 (25.4%) developed septic shock. Seventy patients (66.0%) developed severe neurological symptoms. Ninety-seven patients (91.5%) were treated with plasma exchange and 50 patients (47.2%) received eculizumab (monoclonal anti-C5 antibody). The mortality rate was 4.7%. Mild residual neurological symptoms were present in 21.7% of patients at ICU discharge, and no patient required renal replacement therapy 6 months after ICU admission. Conclusions: During the 2011 Shiga toxin–producing E. coli–associated hemolytic uremic syndrome outbreak in Germany, critical illness developed rapidly after hospital admission, often in young women. The infection was associated with severe neurological and renal symptoms, requiring mechanical ventilation and renal replacement therapy in a substantial proportion of patients. Overall, recovery was much better than expected." @default.
- W1984467110 created "2016-06-24" @default.
- W1984467110 creator A5010761980 @default.
- W1984467110 creator A5014261602 @default.
- W1984467110 creator A5014924899 @default.
- W1984467110 creator A5020297199 @default.
- W1984467110 creator A5021268165 @default.
- W1984467110 creator A5023114984 @default.
- W1984467110 creator A5033750591 @default.
- W1984467110 creator A5036250050 @default.
- W1984467110 creator A5036783314 @default.
- W1984467110 creator A5038348127 @default.
- W1984467110 creator A5040494349 @default.
- W1984467110 creator A5049355867 @default.
- W1984467110 creator A5052268204 @default.
- W1984467110 creator A5054492137 @default.
- W1984467110 creator A5061175108 @default.
- W1984467110 creator A5076351525 @default.
- W1984467110 creator A5078095219 @default.
- W1984467110 creator A5079018056 @default.
- W1984467110 date "2013-07-01" @default.
- W1984467110 modified "2023-10-09" @default.
- W1984467110 title "Clinical Features of Critically Ill Patients With Shiga Toxin–Induced Hemolytic Uremic Syndrome" @default.
- W1984467110 cites W1870404453 @default.
- W1984467110 cites W2002364878 @default.
- W1984467110 cites W2004888237 @default.
- W1984467110 cites W2012630248 @default.
- W1984467110 cites W2032368204 @default.
- W1984467110 cites W2033118339 @default.
- W1984467110 cites W2034135358 @default.
- W1984467110 cites W2040848564 @default.
- W1984467110 cites W2074462360 @default.
- W1984467110 cites W2088863425 @default.
- W1984467110 cites W2092977398 @default.
- W1984467110 cites W2096322533 @default.
- W1984467110 cites W2099514668 @default.
- W1984467110 cites W2104764426 @default.
- W1984467110 cites W2108880106 @default.
- W1984467110 cites W2120835187 @default.
- W1984467110 cites W2133831708 @default.
- W1984467110 cites W2134334494 @default.
- W1984467110 cites W2142898494 @default.
- W1984467110 cites W2148958087 @default.
- W1984467110 cites W2154713526 @default.
- W1984467110 cites W2155849565 @default.
- W1984467110 cites W2156242960 @default.
- W1984467110 cites W2159548036 @default.
- W1984467110 cites W2327529204 @default.
- W1984467110 cites W2332582324 @default.
- W1984467110 cites W86743544 @default.
- W1984467110 doi "https://doi.org/10.1097/ccm.0b013e31828a24a8" @default.
- W1984467110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23660733" @default.
- W1984467110 hasPublicationYear "2013" @default.
- W1984467110 type Work @default.
- W1984467110 sameAs 1984467110 @default.
- W1984467110 citedByCount "25" @default.
- W1984467110 countsByYear W19844671102014 @default.
- W1984467110 countsByYear W19844671102015 @default.
- W1984467110 countsByYear W19844671102016 @default.
- W1984467110 countsByYear W19844671102017 @default.
- W1984467110 countsByYear W19844671102018 @default.
- W1984467110 countsByYear W19844671102020 @default.
- W1984467110 countsByYear W19844671102021 @default.
- W1984467110 crossrefType "journal-article" @default.
- W1984467110 hasAuthorship W1984467110A5010761980 @default.
- W1984467110 hasAuthorship W1984467110A5014261602 @default.
- W1984467110 hasAuthorship W1984467110A5014924899 @default.
- W1984467110 hasAuthorship W1984467110A5020297199 @default.
- W1984467110 hasAuthorship W1984467110A5021268165 @default.
- W1984467110 hasAuthorship W1984467110A5023114984 @default.
- W1984467110 hasAuthorship W1984467110A5033750591 @default.
- W1984467110 hasAuthorship W1984467110A5036250050 @default.
- W1984467110 hasAuthorship W1984467110A5036783314 @default.
- W1984467110 hasAuthorship W1984467110A5038348127 @default.
- W1984467110 hasAuthorship W1984467110A5040494349 @default.
- W1984467110 hasAuthorship W1984467110A5049355867 @default.
- W1984467110 hasAuthorship W1984467110A5052268204 @default.
- W1984467110 hasAuthorship W1984467110A5054492137 @default.
- W1984467110 hasAuthorship W1984467110A5061175108 @default.
- W1984467110 hasAuthorship W1984467110A5076351525 @default.
- W1984467110 hasAuthorship W1984467110A5078095219 @default.
- W1984467110 hasAuthorship W1984467110A5079018056 @default.
- W1984467110 hasConcept C104317684 @default.
- W1984467110 hasConcept C116675565 @default.
- W1984467110 hasConcept C126322002 @default.
- W1984467110 hasConcept C142724271 @default.
- W1984467110 hasConcept C185592680 @default.
- W1984467110 hasConcept C2777080012 @default.
- W1984467110 hasConcept C2777628635 @default.
- W1984467110 hasConcept C2778384902 @default.
- W1984467110 hasConcept C2778411228 @default.
- W1984467110 hasConcept C2779541074 @default.
- W1984467110 hasConcept C547475151 @default.
- W1984467110 hasConcept C55493867 @default.
- W1984467110 hasConcept C71924100 @default.
- W1984467110 hasConceptScore W1984467110C104317684 @default.
- W1984467110 hasConceptScore W1984467110C116675565 @default.
- W1984467110 hasConceptScore W1984467110C126322002 @default.