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• W1984474513 abstract "3D amoeboid cell migration is central to many developmental and disease-related processes such as cancer metastasis. Here, we identify a unique prototypic amoeboid cell migration mode in early zebrafish embryos, termed stable-bleb migration. Stable-bleb cells display an invariant polarized balloon-like shape with exceptional migration speed and persistence. Progenitor cells can be reversibly transformed into stable-bleb cells irrespective of their primary fate and motile characteristics by increasing myosin II activity through biochemical or mechanical stimuli. Using a combination of theory and experiments, we show that, in stable-bleb cells, cortical contractility fluctuations trigger a stochastic switch into amoeboid motility, and a positive feedback between cortical flows and gradients in contractility maintains stable-bleb cell polarization. We further show that rearward cortical flows drive stable-bleb cell migration in various adhesive and non-adhesive environments, unraveling a highly versatile amoeboid migration phenotype." @default.
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• W1984474513 date "2015-02-01" @default.
• W1984474513 modified "2023-10-18" @default.
• W1984474513 title "Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility" @default.
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• W1984474513 doi "https://doi.org/10.1016/j.cell.2015.01.008" @default.
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