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- W1984482587 abstract "Hypoxia is the most important stimulus leading to upregulation of VEGF in the retina and this is caused by accumulation of hypoxia-inducible factors-1 α (HIF-1 α ) protein. The effects of zeaxanthin, a natural phytochemical, on the VEGF and HIF-1 α expression in the primary culture of human retinal pigment epithelial (RPE) cells were studied. An in vitro RPE cell hypoxia model was established by placing cells under 1% oxygen pressure or by adding cobalt chloride (CoCl 2 ) to the culture medium. RPE cells and conditioned media were collected from cultures treated with and without zeaxanthin under normoxic and hypoxic conditions. VEGF and HIF-1 α protein and RNA levels were measured by ELISA kits and RT-PCR, respectively. Hypoxia caused a significant increase of VEGF expression and accumulation of HIF-1 α in RPE cells. Zeaxanthin at 50–150 μ M significantly inhibited the expression of VEGF and accumulation of HIF-1 α protein caused by hypoxia but did not affect expression of VEGF and HIF-1 α under normoxic conditions. This is the first report on the effect of zeaxanthin on VEGF and HIF-1 α levels in cultured RPE cells and suggests that zeaxanthin may have potential value in the prevention and treatment of various retinal diseases associated with vascular leakage and neovascularization." @default.
- W1984482587 created "2016-06-24" @default.
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- W1984482587 date "2015-01-01" @default.
- W1984482587 modified "2023-10-17" @default.
- W1984482587 title "Zeaxanthin Inhibits Hypoxia-Induced VEGF Secretion by RPE Cells through Decreased Protein Levels of Hypoxia-Inducible Factors-1<i>α</i>" @default.
- W1984482587 cites W101845975 @default.
- W1984482587 cites W1516801409 @default.
- W1984482587 cites W1523693806 @default.
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- W1984482587 cites W1550989298 @default.
- W1984482587 cites W1557190248 @default.
- W1984482587 cites W1576741560 @default.
- W1984482587 cites W1776177507 @default.
- W1984482587 cites W1964875773 @default.
- W1984482587 cites W1965809898 @default.
- W1984482587 cites W1966356536 @default.
- W1984482587 cites W1967004211 @default.
- W1984482587 cites W1967004561 @default.
- W1984482587 cites W1970068068 @default.
- W1984482587 cites W1972454552 @default.
- W1984482587 cites W1979143271 @default.
- W1984482587 cites W1981887843 @default.
- W1984482587 cites W1987154388 @default.
- W1984482587 cites W1987261488 @default.
- W1984482587 cites W1988697413 @default.
- W1984482587 cites W1990380079 @default.
- W1984482587 cites W1992047040 @default.
- W1984482587 cites W1992091033 @default.
- W1984482587 cites W1992267606 @default.
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- W1984482587 cites W2025980027 @default.
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- W1984482587 cites W2027875367 @default.
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- W1984482587 cites W2045289944 @default.
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- W1984482587 cites W2063747172 @default.
- W1984482587 cites W2067328080 @default.
- W1984482587 cites W2068230682 @default.
- W1984482587 cites W2070135193 @default.
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- W1984482587 cites W2165196471 @default.
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- W1984482587 cites W2171524333 @default.
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- W1984482587 cites W2608488415 @default.
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- W1984482587 doi "https://doi.org/10.1155/2015/687386" @default.
- W1984482587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4320873" @default.
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- W1984482587 hasPublicationYear "2015" @default.
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