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- W1984486346 abstract "A stability-indicating high-performance liquid chromatography method to quantify 2-(2,4-difluorophenyl)-4,5,6,7-tetrafluoroisoindoline-1,3-dione (NSC-726796) and its three main degradation products was developed. This method was used to investigate its degradation kinetics and mechanism. The reaction follows first-order kinetics and appears to be base catalyzed with the maximum stability at pH 1. The products were identified as 2-(2,4-difluorophenylcarbamoyl)-3,4,5,6-tetrafluorobenzoic acid (NSC-749820), 2,4-difluoroaniline, and tetrafluorophthalic acid. The parent drug, NSC-726796, was also found to react with methanol and ethanol. NSC-726796 demonstrates antiangiogenic activity, however, when its degradant NSC749820 does not show antiangiogenic activity." @default.
- W1984486346 created "2016-06-24" @default.
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- W1984486346 date "2012-05-03" @default.
- W1984486346 modified "2023-10-06" @default.
- W1984486346 title "Preformulation Study of NSC-726796" @default.
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- W1984486346 doi "https://doi.org/10.1208/s12249-012-9784-5" @default.
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