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- W1984489001 abstract "Abstract Zymosan (ZYM), a strong complement activating yeast cell preparation, is also a potent inflammatory substance, which shows immunopharmacological activity. Major component of ZYM is β-glucan but contains other constituents, such as mannan, protein, and nucleic acid. We applied sodium hypochlorite (NaClO) treatment to ZYM to reduce impurities and compared the activity with native/parent ZYM. Oxidized ZYM (OX-ZYM) became a nitrogen-free agent. By NMR analysis of native OX-ZYM and zymolyase (endo-1,3-β-glucanase) digest, OX-ZYM was found to contain 1,3-β-linked and 1,6-β-linked glucan moieties, while the latter degraded by sodium metaperiodate treatment. OX-ZYM also contained small amounts of anionic groups, partly reducible by sodium borohydride. Degree of polymerization (DP) of 1,6-β-glucan moiety was estimated to be about DP10–DP50 by MALDI-TOF-MS analysis. In comparison with ZYM activities, OX-ZYM and derivatives showed strong antitumor activity to solid form of Sarcoma 180 in mice, and showed strong activity on alternative pathway of complement, but lost secondary response to ZYM-immune mice. These facts strongly suggested that a particulate form of β-glucan was prepared by NaClO treatment of ZYM and at least a part of ZYM-mediated biological activity was found unmediated by β-glucan moiety." @default.
- W1984489001 created "2016-06-24" @default.
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- W1984489001 date "2001-04-01" @default.
- W1984489001 modified "2023-10-18" @default.
- W1984489001 title "Structure and biological activities of hypochlorite oxidized zymosan" @default.
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- W1984489001 doi "https://doi.org/10.1016/s0144-8617(00)00250-2" @default.
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