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- W1984496694 abstract "The field of cancer therapy is rapidly moving forward with the development of numerous prospective new agents designed to inhibit cellular factors involved in signal transduction, cell proliferation, and the onset of apoptosis. At the core of these biological processes are transcription factors that are the functional mediators of these effects. Transcription factors are the downstream targets of numerous signal transduction pathways that are central to the process of carcinogenesis. The Activator Protein-1 (AP-1) complex is one such factor that has a central role in multiple processes involved in tumorigenesis including proliferation, migration, invasion and metastasis. The focus of this review is, using AP- 1 as a model, to discuss transcription factors as targets for cancer therapy. The feasibility of targeted disruption of AP-1 by various agents such as dominant-negative mutants, small molecule inhibitors, transcription factor decoys (TFD), chemotherapeutic drugs, chemoprevention agents, siRNA and natural products will be explored. Keywords: Cancer therapy, transcription factors, AP-1, dominant-negative mutants, TF-decoys, RNAi, small molecule inhibitors" @default.
- W1984496694 created "2016-06-24" @default.
- W1984496694 creator A5012684686 @default.
- W1984496694 creator A5065550697 @default.
- W1984496694 creator A5081561534 @default.
- W1984496694 date "2007-02-01" @default.
- W1984496694 modified "2023-09-29" @default.
- W1984496694 title "Transcription Factors as Targets for Cancer Therapy: AP-1 a Potential Therapeutic Target" @default.
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- W1984496694 doi "https://doi.org/10.2174/157339407780126665" @default.
- W1984496694 hasPublicationYear "2007" @default.
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