FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984498889> ?p ?o ?g. }

• W1984498889 endingPage "1445" @default.
• W1984498889 startingPage "1437" @default.
• W1984498889 abstract "Activating transcription factor-3 (ATF3) is a member of the ATF/CREB transcription factor superfamily and is induced in dorsal root ganglion (DRG) cells after nerve injury. In order to study the regulation of ATF3, we have examined the effect of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) on ATF3 expression. In untreated rats, sciatic nerve transection induced ATF3 immunoreactivity in 82% of L4 DRG cells at 14 days after axotomy. Intrathecal delivery of NGF or GDNF for 2 weeks commencing immediately after injury reduced the ATF3 expression to 35 and 23% of DRG cells, respectively. Cell size analysis indicated that NGF had protected a population of mainly small- to medium-sized cells, but that the GDNF had protected a population of both small and large cells. This effect was confirmed by double labelling for P2X(3), CGRP and 200 kDa neurofilament, markers for small peptide-poor cells, peptide-rich cells and large cells, respectively. Thus GDNF reduced the percentage of ATF3-immunoreactive P2X(3) cells from 70 to 4%, and the percentage of ATF3-immunoreactive neurofilament cells from 63 to 24%. NGF was less effective than GDNF in reducing ATF3 expression in these cell types, but reduced the percentage of ATF3-immunoreactive CGRP cells from 10% to < 1%. These results show that ATF3 expression in specific populations of DRG cells can be modulated by exogenous supplementation of specific trophic factors, and suggest that ATF3 expression may normally be induced by the loss of target-derived NGF and GDNF." @default.
• W1984498889 created "2016-06-24" @default.
• W1984498889 creator A5007880093 @default.
• W1984498889 creator A5009201799 @default.
• W1984498889 creator A5009637321 @default.
• W1984498889 creator A5016047236 @default.
• W1984498889 creator A5036506943 @default.
• W1984498889 creator A5065656870 @default.
• W1984498889 creator A5068821729 @default.
• W1984498889 creator A5070728399 @default.
• W1984498889 date "2004-03-01" @default.
• W1984498889 modified "2023-10-18" @default.
• W1984498889 title "NGF and GDNF ameliorate the increase in ATF3 expression which occurs in dorsal root ganglion cells in response to peripheral nerve injury" @default.
• W1984498889 cites W1496712622 @default.
• W1984498889 cites W1655117540 @default.
• W1984498889 cites W1714355435 @default.
• W1984498889 cites W1904734022 @default.
• W1984498889 cites W1914763441 @default.
• W1984498889 cites W1933310320 @default.
• W1984498889 cites W1967672185 @default.
• W1984498889 cites W1971644755 @default.
• W1984498889 cites W1974300877 @default.
• W1984498889 cites W1975920213 @default.
• W1984498889 cites W1981697384 @default.
• W1984498889 cites W1982095811 @default.
• W1984498889 cites W1986559713 @default.
• W1984498889 cites W1989231576 @default.
• W1984498889 cites W2000845719 @default.
• W1984498889 cites W2019579305 @default.
• W1984498889 cites W2031039258 @default.
• W1984498889 cites W2032733634 @default.
• W1984498889 cites W2040035374 @default.
• W1984498889 cites W2042599031 @default.
• W1984498889 cites W2042847772 @default.
• W1984498889 cites W2043187683 @default.
• W1984498889 cites W2049923998 @default.
• W1984498889 cites W2061135681 @default.
• W1984498889 cites W2063525911 @default.
• W1984498889 cites W2064963239 @default.
• W1984498889 cites W2071595010 @default.
• W1984498889 cites W2073099311 @default.
• W1984498889 cites W2074263579 @default.
• W1984498889 cites W2083107042 @default.
• W1984498889 cites W2083576051 @default.
• W1984498889 cites W2090305787 @default.
• W1984498889 cites W2098296304 @default.
• W1984498889 cites W2099173554 @default.
• W1984498889 cites W2112382187 @default.
• W1984498889 cites W2113723285 @default.
• W1984498889 cites W2117806919 @default.
• W1984498889 cites W2135600240 @default.
• W1984498889 cites W2138564138 @default.
• W1984498889 cites W2145277005 @default.
• W1984498889 cites W2154617206 @default.
• W1984498889 cites W2159872853 @default.
• W1984498889 cites W2163383917 @default.
• W1984498889 cites W2167144831 @default.
• W1984498889 doi "https://doi.org/10.1111/j.1460-9568.2004.03241.x" @default.
• W1984498889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15066140" @default.
• W1984498889 hasPublicationYear "2004" @default.
• W1984498889 type Work @default.
• W1984498889 sameAs 1984498889 @default.
• W1984498889 citedByCount "113" @default.
• W1984498889 countsByYear W19844988892012 @default.
• W1984498889 countsByYear W19844988892013 @default.
• W1984498889 countsByYear W19844988892014 @default.
• W1984498889 countsByYear W19844988892015 @default.
• W1984498889 countsByYear W19844988892016 @default.
• W1984498889 countsByYear W19844988892017 @default.
• W1984498889 countsByYear W19844988892018 @default.
• W1984498889 countsByYear W19844988892019 @default.
• W1984498889 countsByYear W19844988892020 @default.
• W1984498889 countsByYear W19844988892021 @default.
• W1984498889 countsByYear W19844988892022 @default.
• W1984498889 countsByYear W19844988892023 @default.
• W1984498889 crossrefType "journal-article" @default.
• W1984498889 hasAuthorship W1984498889A5007880093 @default.
• W1984498889 hasAuthorship W1984498889A5009201799 @default.
• W1984498889 hasAuthorship W1984498889A5009637321 @default.
• W1984498889 hasAuthorship W1984498889A5016047236 @default.
• W1984498889 hasAuthorship W1984498889A5036506943 @default.
• W1984498889 hasAuthorship W1984498889A5065656870 @default.
• W1984498889 hasAuthorship W1984498889A5068821729 @default.
• W1984498889 hasAuthorship W1984498889A5070728399 @default.
• W1984498889 hasConcept C101762097 @default.
• W1984498889 hasConcept C104317684 @default.
• W1984498889 hasConcept C126322002 @default.
• W1984498889 hasConcept C134018914 @default.
• W1984498889 hasConcept C139447449 @default.
• W1984498889 hasConcept C150194340 @default.
• W1984498889 hasConcept C157207234 @default.
• W1984498889 hasConcept C157880135 @default.
• W1984498889 hasConcept C158617107 @default.
• W1984498889 hasConcept C160539049 @default.
• W1984498889 hasConcept C169760540 @default.
• W1984498889 hasConcept C170493617 @default.
• W1984498889 hasConcept C185592680 @default.
• W1984498889 hasConcept C185856081 @default.

• next