FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984507564> ?p ?o ?g. }

• W1984507564 endingPage "340" @default.
• W1984507564 startingPage "336" @default.
• W1984507564 abstract "We examined the relative effects of thyrotropin (TSH) and TSH receptor autoantibodies in the sera of patients with autoimmune thyroid disease on three TSH-lutropin/chorionic gonadotropin (LH/CG) receptor extracellular domain chimeras. Each chimera binds TSH with high affinity. Only the chimera with TSH receptor extracellular domains ABC (amino acids 1-260) had a functional (cAMP) response to thyroid stimulatory IgG. The chimeras with TSH receptor domains CD (amino acids 171-360) and DE (amino acids 261-418) were unresponsive. The lack of response of the chimera with TSH receptor domains DE was anticipated because it fails to transduce a signal with TSH stimulation, unlike the other two chimeras. A different spectrum of responses occurred when the TSH-LH/CG chimeras were examined in terms of autoantibody competition for TSH binding. IgG with TSH binding-inhibitory activity when tested with the wild-type TSH receptor also inhibited TSH binding to the chimera with TSH receptor domains DE. Dramatically, however, these IgG did not inhibit TSH binding to the chimera with TSH receptor domains CD, and had weak or absent activity with the chimera with TSH receptor domains ABC. Chimeras with TSH receptor domains ABC and DE were equally effective in affinity-purifying IgG with thyroid-stimulatory and TSH binding-inhibitory activities. Nonstimulatory IgG with TSH binding-inhibitory activity inhibited the action of stimulatory IgG on the wild-type TSH receptor, but not with the chimera containing TSH receptor domains ABC. In summary, TSH receptor autoantibodies and TSH bind to regions in both domains ABC and DE of the TSH receptor extracellular region. Stimulatory and inhibitory TSH receptor autoantibodies, as well as TSH, appear to bind to different sites in domains ABC, but similar sites in domains DE, of the receptor. Alternatively, TSH and the different TSH receptor antibodies bind with differing affinities to the same site in the ABC region." @default.
• W1984507564 created "2016-06-24" @default.
• W1984507564 creator A5027192215 @default.
• W1984507564 creator A5031642047 @default.
• W1984507564 creator A5039924463 @default.
• W1984507564 creator A5055826150 @default.
• W1984507564 creator A5085029122 @default.
• W1984507564 date "1991-07-01" @default.
• W1984507564 modified "2023-10-13" @default.
• W1984507564 title "Binding domains of stimulatory and inhibitory thyrotropin (TSH) receptor autoantibodies determined with chimeric TSH-lutropin/chorionic gonadotropin receptors." @default.
• W1984507564 cites W1970181624 @default.
• W1984507564 cites W1970725961 @default.
• W1984507564 cites W1971073727 @default.
• W1984507564 cites W1984569673 @default.
• W1984507564 cites W1985750220 @default.
• W1984507564 cites W1987572316 @default.
• W1984507564 cites W1990110463 @default.
• W1984507564 cites W1993401712 @default.
• W1984507564 cites W2001676232 @default.
• W1984507564 cites W2012527285 @default.
• W1984507564 cites W2019972073 @default.
• W1984507564 cites W2022836621 @default.
• W1984507564 cites W2035150538 @default.
• W1984507564 cites W2041084319 @default.
• W1984507564 cites W2047286461 @default.
• W1984507564 cites W2055180387 @default.
• W1984507564 cites W2059665365 @default.
• W1984507564 cites W2066387623 @default.
• W1984507564 cites W2067700116 @default.
• W1984507564 cites W2069468683 @default.
• W1984507564 cites W2071830593 @default.
• W1984507564 cites W2071939459 @default.
• W1984507564 cites W2078357110 @default.
• W1984507564 cites W2079449352 @default.
• W1984507564 cites W2080925634 @default.
• W1984507564 cites W2092753353 @default.
• W1984507564 cites W2093909923 @default.
• W1984507564 cites W2102608765 @default.
• W1984507564 cites W2113530505 @default.
• W1984507564 cites W2116872501 @default.
• W1984507564 cites W2140195025 @default.
• W1984507564 cites W2152255652 @default.
• W1984507564 cites W2173256032 @default.
• W1984507564 doi "https://doi.org/10.1172/jci115297" @default.
• W1984507564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/296038" @default.
• W1984507564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1711544" @default.
• W1984507564 hasPublicationYear "1991" @default.
• W1984507564 type Work @default.
• W1984507564 sameAs 1984507564 @default.
• W1984507564 citedByCount "147" @default.
• W1984507564 countsByYear W19845075642012 @default.
• W1984507564 countsByYear W19845075642013 @default.
• W1984507564 countsByYear W19845075642015 @default.
• W1984507564 countsByYear W19845075642016 @default.
• W1984507564 countsByYear W19845075642017 @default.
• W1984507564 countsByYear W19845075642018 @default.
• W1984507564 countsByYear W19845075642020 @default.
• W1984507564 countsByYear W19845075642021 @default.
• W1984507564 crossrefType "journal-article" @default.
• W1984507564 hasAuthorship W1984507564A5027192215 @default.
• W1984507564 hasAuthorship W1984507564A5031642047 @default.
• W1984507564 hasAuthorship W1984507564A5039924463 @default.
• W1984507564 hasAuthorship W1984507564A5055826150 @default.
• W1984507564 hasAuthorship W1984507564A5085029122 @default.
• W1984507564 hasBestOaLocation W19845075641 @default.
• W1984507564 hasConcept C104317684 @default.
• W1984507564 hasConcept C126322002 @default.
• W1984507564 hasConcept C134018914 @default.
• W1984507564 hasConcept C159654299 @default.
• W1984507564 hasConcept C163764329 @default.
• W1984507564 hasConcept C170493617 @default.
• W1984507564 hasConcept C185592680 @default.
• W1984507564 hasConcept C203014093 @default.
• W1984507564 hasConcept C2776652619 @default.
• W1984507564 hasConcept C2777608072 @default.
• W1984507564 hasConcept C2778782382 @default.
• W1984507564 hasConcept C30278631 @default.
• W1984507564 hasConcept C526584372 @default.
• W1984507564 hasConcept C55493867 @default.
• W1984507564 hasConcept C71315377 @default.
• W1984507564 hasConcept C71924100 @default.
• W1984507564 hasConcept C86803240 @default.
• W1984507564 hasConceptScore W1984507564C104317684 @default.
• W1984507564 hasConceptScore W1984507564C126322002 @default.
• W1984507564 hasConceptScore W1984507564C134018914 @default.
• W1984507564 hasConceptScore W1984507564C159654299 @default.
• W1984507564 hasConceptScore W1984507564C163764329 @default.
• W1984507564 hasConceptScore W1984507564C170493617 @default.
• W1984507564 hasConceptScore W1984507564C185592680 @default.
• W1984507564 hasConceptScore W1984507564C203014093 @default.
• W1984507564 hasConceptScore W1984507564C2776652619 @default.
• W1984507564 hasConceptScore W1984507564C2777608072 @default.
• W1984507564 hasConceptScore W1984507564C2778782382 @default.
• W1984507564 hasConceptScore W1984507564C30278631 @default.
• W1984507564 hasConceptScore W1984507564C526584372 @default.
• W1984507564 hasConceptScore W1984507564C55493867 @default.
• W1984507564 hasConceptScore W1984507564C71315377 @default.
• W1984507564 hasConceptScore W1984507564C71924100 @default.

• next