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• W1984508731 abstract "Prior studies on the transcription of erythrovirus B19 have identified a short leader sequence associated with all spliced viral transcripts. While some variability has been observed in the acceptor for this first intron, studies to date in both permissive and nonpermissive cell types have reported a unique splice donor site. In the semipermissive MB-02 cell line, we have found that splicing of this first intron proceeds almost exclusively via a cryptic CT donor downstream of the previously reported GT donor at nucleotide 406. The resulting messages for the viral structural proteins and 11-kDa protein are thereby made bicistronic, with the first expressible polypeptide being a 34 amino acid fusion of the NS-1 and 7.5-kDa proteins. The presence of an upstream open-reading frame on these messages is likely to block effective translation of the downstream structural protein products. We propose this as a significant mechanism in determining B19's tropism on the basis of host cell splicing machinery, and present evidence in support of this model. Additionally, this is the first report of usage of a noncanonical splice donor in B19, and to our knowledge the first report of a CT-AG splice in any system." @default.
• W1984508731 created "2016-06-24" @default.
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• W1984508731 date "2000-09-01" @default.
• W1984508731 modified "2023-09-27" @default.
• W1984508731 title "Identification of a Novel RNA Splicing Pattern as a Basis of Restricted Cell Tropism of Erythrovirus B19" @default.
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• W1984508731 doi "https://doi.org/10.1006/viro.2000.0460" @default.
• W1984508731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10964772" @default.
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