FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984509557> ?p ?o ?g. }

• W1984509557 endingPage "2073" @default.
• W1984509557 startingPage "2067" @default.
• W1984509557 abstract "Aminoglycoside antibiotics are pseudosaccharides decorated with ammonium groups that are critical for their potent broad-spectrum antibacterial activity. Despite over three decades of speculation whether or not modulation of pKa is a viable strategy to curtail aminoglycoside kidney toxicity, there is a lack of methods to systematically probe amine-RNA interactions and resultant cytotoxicity trends. This study reports the first series of potent aminoglycoside antibiotics harboring fluorinated N1-hydroxyaminobutyryl acyl (HABA) appendages for which fluorine-RNA contacts are revealed through an X-ray cocrystal structure within the RNA A-site. Cytotoxicity in kidney-derived cells was significantly reduced for the derivative featuring our novel β,β-difluoro-HABA group, which masks one net charge by lowering the pKa without compromising antibacterial potency. This novel side-chain assists in evasion of aminoglycoside-modifying enzymes, and it can be easily transferred to impart these properties onto any number of novel analogs." @default.
• W1984509557 created "2016-06-24" @default.
• W1984509557 creator A5008646077 @default.
• W1984509557 creator A5011675487 @default.
• W1984509557 creator A5031715087 @default.
• W1984509557 creator A5036167219 @default.
• W1984509557 creator A5039513759 @default.
• W1984509557 creator A5042632655 @default.
• W1984509557 creator A5056270175 @default.
• W1984509557 creator A5061519281 @default.
• W1984509557 creator A5062983432 @default.
• W1984509557 creator A5070036659 @default.
• W1984509557 creator A5070828638 @default.
• W1984509557 creator A5073375883 @default.
• W1984509557 creator A5080140815 @default.
• W1984509557 creator A5088901227 @default.
• W1984509557 date "2014-07-14" @default.
• W1984509557 modified "2023-10-03" @default.
• W1984509557 title "Toxicity Modulation, Resistance Enzyme Evasion, and A-Site X-ray Structure of Broad-Spectrum Antibacterial Neomycin Analogs" @default.
• W1984509557 cites W1927502485 @default.
• W1984509557 cites W1960965614 @default.
• W1984509557 cites W1965472603 @default.
• W1984509557 cites W1997061783 @default.
• W1984509557 cites W2006942628 @default.
• W1984509557 cites W2008256945 @default.
• W1984509557 cites W2026362317 @default.
• W1984509557 cites W2035749246 @default.
• W1984509557 cites W2060360946 @default.
• W1984509557 cites W2061188620 @default.
• W1984509557 cites W2075590188 @default.
• W1984509557 cites W2078652451 @default.
• W1984509557 cites W2083734806 @default.
• W1984509557 cites W2085844328 @default.
• W1984509557 cites W2093649670 @default.
• W1984509557 cites W2094022494 @default.
• W1984509557 cites W2099925248 @default.
• W1984509557 cites W2104276827 @default.
• W1984509557 cites W2112756982 @default.
• W1984509557 cites W2115486016 @default.
• W1984509557 cites W2116214229 @default.
• W1984509557 cites W2117430673 @default.
• W1984509557 cites W2117705258 @default.
• W1984509557 cites W2119966574 @default.
• W1984509557 cites W2128912763 @default.
• W1984509557 cites W2139774433 @default.
• W1984509557 cites W2165059987 @default.
• W1984509557 cites W2169005164 @default.
• W1984509557 cites W2169800903 @default.
• W1984509557 cites W2170243611 @default.
• W1984509557 cites W2195509077 @default.
• W1984509557 cites W2331105855 @default.
• W1984509557 cites W4211018016 @default.
• W1984509557 cites W4212958671 @default.
• W1984509557 cites W4234869086 @default.
• W1984509557 doi "https://doi.org/10.1021/cb5003416" @default.
• W1984509557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25019242" @default.
• W1984509557 hasPublicationYear "2014" @default.
• W1984509557 type Work @default.
• W1984509557 sameAs 1984509557 @default.
• W1984509557 citedByCount "21" @default.
• W1984509557 countsByYear W19845095572015 @default.
• W1984509557 countsByYear W19845095572016 @default.
• W1984509557 countsByYear W19845095572017 @default.
• W1984509557 countsByYear W19845095572018 @default.
• W1984509557 countsByYear W19845095572020 @default.
• W1984509557 countsByYear W19845095572021 @default.
• W1984509557 countsByYear W19845095572022 @default.
• W1984509557 crossrefType "journal-article" @default.
• W1984509557 hasAuthorship W1984509557A5008646077 @default.
• W1984509557 hasAuthorship W1984509557A5011675487 @default.
• W1984509557 hasAuthorship W1984509557A5031715087 @default.
• W1984509557 hasAuthorship W1984509557A5036167219 @default.
• W1984509557 hasAuthorship W1984509557A5039513759 @default.
• W1984509557 hasAuthorship W1984509557A5042632655 @default.
• W1984509557 hasAuthorship W1984509557A5056270175 @default.
• W1984509557 hasAuthorship W1984509557A5061519281 @default.
• W1984509557 hasAuthorship W1984509557A5062983432 @default.
• W1984509557 hasAuthorship W1984509557A5070036659 @default.
• W1984509557 hasAuthorship W1984509557A5070828638 @default.
• W1984509557 hasAuthorship W1984509557A5073375883 @default.
• W1984509557 hasAuthorship W1984509557A5080140815 @default.
• W1984509557 hasAuthorship W1984509557A5088901227 @default.
• W1984509557 hasConcept C104317684 @default.
• W1984509557 hasConcept C109316439 @default.
• W1984509557 hasConcept C181199279 @default.
• W1984509557 hasConcept C185592680 @default.
• W1984509557 hasConcept C202751555 @default.
• W1984509557 hasConcept C2777787772 @default.
• W1984509557 hasConcept C2779841869 @default.
• W1984509557 hasConcept C2780104969 @default.
• W1984509557 hasConcept C501593827 @default.
• W1984509557 hasConcept C523546767 @default.
• W1984509557 hasConcept C54355233 @default.
• W1984509557 hasConcept C55493867 @default.
• W1984509557 hasConcept C67705224 @default.
• W1984509557 hasConcept C71240020 @default.
• W1984509557 hasConcept C86803240 @default.
• W1984509557 hasConceptScore W1984509557C104317684 @default.

• next