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- W1984510309 abstract "The aim of the present study was to investigate the impact of isoflurane on regional neurogenic mechanisms in the control of vascular tone.Therefore, regional determinations of sympathetic activity and hemodynamics were made in chloralose-anesthetized swine before and during administration of 1.4% isoflurane. Sympathetic activity was examined from spillover of norepinephrine (NE) into the circulation using an isotope dilution technique. Administration of isoflurane caused a marked decrease in mesenteric (65 +/- 9 pmol centered dot min-1 centered dot 100 g-1; P < 0.05) NE spillover. Renal NE spillover was moderately decreased (25 +/- 6 pmol centered dot min-1 centered dot 100 g-1; P < 0.05), whereas liver NE spillover did not change significantly during isoflurane administration, suggesting that liver sympathetic activity is maintained at this level of isoflurane anesthesia. Total body NE spillover decreased (13 +/- 2 pmol centered dot min-1 centered dot 100 g-1, P < 0.05). Thus, isoflurane affected sympathetic outflow in a regionally differentiated pattern. Significant correlations were found between total body, mesenteric, and renal NE spillovers and vascular resistances, supporting the concept that the observed reductions in vascular resistances in these circulations during isoflurane administration were in part a consequence of reduced sympathetic outflow. In the liver circulation, no correlation was found between NE spillover and liver portal or liver arterial vascular resistances. Liver arterial resistance was significantly reduced during isoflurane administration while liver portal resistance was unchanged. Administration of isoflurane caused reductions in cardiac output, renal, portal, hepatic arterial, and total hepatic blood flows, whereas mesenteric blood flow was unchanged. To summarize, isoflurane decreased mesenteric and renal NE spillover with concomitant reductions in vascular resistances. Liver NE spillover was, however, not changed, and no correlations to hepatic arterial and hepatic portal resistances were found. Thus, the effect of 1.4% isoflurane on sympathetic discharge and hemodynamics showed a differential pattern. (Anesth Analg 1995;80:135-42)" @default.
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- W1984510309 date "1995-01-01" @default.
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- W1984510309 title "Splanchnic and Renal Sympathetic Activity in Relation to Hemodynamics During Isoflurane Administration in Pigs" @default.
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- W1984510309 doi "https://doi.org/10.1097/00000539-199501000-00023" @default.
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