FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984542598> ?p ?o ?g. }

• W1984542598 endingPage "877" @default.
• W1984542598 startingPage "868" @default.
• W1984542598 abstract "Clarification of the molecular and cellular mechanisms underlying the assembly of amyloid beta-protein (Abeta) into insoluble fibrils in the brain has been one of the biggest challenges in the research on Alzheimer disease (AD). We previously identified a novel Abeta species, which was characterized by its tight binding to GM1 ganglioside (GM1), in the brain showing early pathological changes of AD. The ganglioside-bound Abeta (GAbeta) possessed unique characteristics, including its altered immunoreactivity, which suggests its distinct conformation from native Abeta, and its strong potency to accelerate Abeta assembly into fibrils. On the basis of these characteristics, it was hypothesized that Abeta adopts an altered conformation following interaction with GM1, leading to the generation of GAbeta, and then GAbeta acts as an endogenous seed for Alzheimer amyloid in the brain. To date, various in vitro and in vivo studies on GAbeta have revealed how Abeta binds to gangliosides, i.e., what are the favorable physicochemical and neurobiological conditions for generating GAbeta, and what is the pathological significance of ganglioside-induced Abeta assembly in the development of AD. Interestingly, GAbeta is favorably generated in the unique ganglioside-enriched (clustered), raft-like microdomains; moreover, amyloid fibrils formed in the presence of gangliosides are neurotoxic. Furthermore, the conformational change of Abeta in the presence of ganglioside has been characterized by an NMR study. In this review, we focus on the recent progress of GAbeta studies and highlight the possibility that ganglioside binding is the initial and common step in the development of a part of human misfolding-type amyloidoses, including AD." @default.
• W1984542598 created "2016-06-24" @default.
• W1984542598 creator A5012808950 @default.
• W1984542598 creator A5047494990 @default.
• W1984542598 creator A5049284705 @default.
• W1984542598 date "2010-08-01" @default.
• W1984542598 modified "2023-10-06" @default.
• W1984542598 title "Aβ polymerization through interaction with membrane gangliosides" @default.
• W1984542598 cites W1482247849 @default.
• W1984542598 cites W1595368494 @default.
• W1984542598 cites W1964823248 @default.
• W1984542598 cites W1965772275 @default.
• W1984542598 cites W1973033763 @default.
• W1984542598 cites W1973475837 @default.
• W1984542598 cites W1976130701 @default.
• W1984542598 cites W1976210162 @default.
• W1984542598 cites W1976824735 @default.
• W1984542598 cites W1977687419 @default.
• W1984542598 cites W1982617198 @default.
• W1984542598 cites W1986800510 @default.
• W1984542598 cites W1989269014 @default.
• W1984542598 cites W1991717070 @default.
• W1984542598 cites W1994928619 @default.
• W1984542598 cites W1998592142 @default.
• W1984542598 cites W2001148193 @default.
• W1984542598 cites W2004098528 @default.
• W1984542598 cites W2007505743 @default.
• W1984542598 cites W2008195256 @default.
• W1984542598 cites W2012129011 @default.
• W1984542598 cites W2012455318 @default.
• W1984542598 cites W2013650907 @default.
• W1984542598 cites W2027846974 @default.
• W1984542598 cites W2027860964 @default.
• W1984542598 cites W2029428787 @default.
• W1984542598 cites W2029695041 @default.
• W1984542598 cites W2033715126 @default.
• W1984542598 cites W2037396758 @default.
• W1984542598 cites W2039049924 @default.
• W1984542598 cites W2050075457 @default.
• W1984542598 cites W2051651977 @default.
• W1984542598 cites W2054194478 @default.
• W1984542598 cites W2058967914 @default.
• W1984542598 cites W2061908854 @default.
• W1984542598 cites W2063272219 @default.
• W1984542598 cites W2067008646 @default.
• W1984542598 cites W2067360371 @default.
• W1984542598 cites W2073516240 @default.
• W1984542598 cites W2075429515 @default.
• W1984542598 cites W2082698296 @default.
• W1984542598 cites W2082974330 @default.
• W1984542598 cites W2087202514 @default.
• W1984542598 cites W2089207885 @default.
• W1984542598 cites W2092552200 @default.
• W1984542598 cites W2094098691 @default.
• W1984542598 cites W2095596299 @default.
• W1984542598 cites W2099077346 @default.
• W1984542598 cites W2112735281 @default.
• W1984542598 cites W2114923908 @default.
• W1984542598 cites W2118280241 @default.
• W1984542598 cites W2119297140 @default.
• W1984542598 cites W2121890455 @default.
• W1984542598 cites W2122294662 @default.
• W1984542598 cites W2130079515 @default.
• W1984542598 cites W2137493263 @default.
• W1984542598 cites W2145686560 @default.
• W1984542598 cites W2146610745 @default.
• W1984542598 cites W2149478284 @default.
• W1984542598 cites W2159367229 @default.
• W1984542598 cites W2162716229 @default.
• W1984542598 cites W2162741488 @default.
• W1984542598 cites W2164727422 @default.
• W1984542598 cites W3142091100 @default.
• W1984542598 cites W1985083676 @default.
• W1984542598 doi "https://doi.org/10.1016/j.bbalip.2010.01.008" @default.
• W1984542598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20117237" @default.
• W1984542598 hasPublicationYear "2010" @default.
• W1984542598 type Work @default.
• W1984542598 sameAs 1984542598 @default.
• W1984542598 citedByCount "198" @default.
• W1984542598 countsByYear W19845425982012 @default.
• W1984542598 countsByYear W19845425982013 @default.
• W1984542598 countsByYear W19845425982014 @default.
• W1984542598 countsByYear W19845425982015 @default.
• W1984542598 countsByYear W19845425982016 @default.
• W1984542598 countsByYear W19845425982017 @default.
• W1984542598 countsByYear W19845425982018 @default.
• W1984542598 countsByYear W19845425982019 @default.
• W1984542598 countsByYear W19845425982020 @default.
• W1984542598 countsByYear W19845425982021 @default.
• W1984542598 countsByYear W19845425982022 @default.
• W1984542598 countsByYear W19845425982023 @default.
• W1984542598 crossrefType "journal-article" @default.
• W1984542598 hasAuthorship W1984542598A5012808950 @default.
• W1984542598 hasAuthorship W1984542598A5047494990 @default.
• W1984542598 hasAuthorship W1984542598A5049284705 @default.
• W1984542598 hasConcept C12554922 @default.
• W1984542598 hasConcept C150903083 @default.
• W1984542598 hasConcept C178790620 @default.

• next