FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984556901> ?p ?o ?g. }

• W1984556901 endingPage "629" @default.
• W1984556901 startingPage "615" @default.
• W1984556901 abstract "Substance P (SP), a tachykinin with a wide range of biological activities including a priming effect on human eosinophil chemotaxis, was investigated for its influence on eosinophil cytotoxic function measured as degranulation of eosinophil-derived neurotoxin (EDN). Peripheral blood was obtained from healthy volunteers and the degranulation assays were performed using radioimmunoassay (RIA). SP and its C-terminal elicited EDN release in a time-dependent mode at a narrow range of doses with optimal activity of 10−6M. FK888 (NK-1 receptor antagonist) inhibited EDN release stimulated by SP in dose dependency, also a complete inhibition was observed when eosinophils were preincubated with 1000ng/ml pertussis toxin (PTX). Pre-exposure of eosinophils to staurosporine resulted in blockage of SP-induced EDN release in a dose-dependent mode. On the other hand, SP at 10−7M and 10−8M primed eosinophils to suboptimal dose (10−8M) of Platelet activating factor (PAF) resulting into significant enhancement of EDN release. SP(4–11) fragment showed a similar activity while SP(1–4) fragment was not active. SP priming of eosinophils was not affected by Ca2+ depletion, however, it caused a change in the pattern of the intracellular calcium influx against the suboptimal dose of PAF. These results suggest that SP i) may induce human eosinophil matrix protein degranulation through a receptor mediated mechanism coupled to PTX sensitive G protein(s) with the probability of linkage to phospholipase C activation, and, ii) primes human eosinophils for an exalted inflammatory response through a Ca2+ independent pathway." @default.
• W1984556901 created "2016-06-24" @default.
• W1984556901 creator A5075819866 @default.
• W1984556901 creator A5087150619 @default.
• W1984556901 creator A5089132962 @default.
• W1984556901 date "1997-01-01" @default.
• W1984556901 modified "2023-10-16" @default.
• W1984556901 title "Mechanisms Involved in Activation of Human Eosinophil Exocytosis by Substance P: An in Vitro Model of Sensory Neuroimmunomodulation" @default.
• W1984556901 cites W1487548491 @default.
• W1984556901 cites W1492927281 @default.
• W1984556901 cites W1510130879 @default.
• W1984556901 cites W1540036539 @default.
• W1984556901 cites W1567957283 @default.
• W1984556901 cites W1589866689 @default.
• W1984556901 cites W1898483334 @default.
• W1984556901 cites W1949381048 @default.
• W1984556901 cites W1963678276 @default.
• W1984556901 cites W1965212424 @default.
• W1984556901 cites W1970183701 @default.
• W1984556901 cites W1974823087 @default.
• W1984556901 cites W1978778326 @default.
• W1984556901 cites W1983792284 @default.
• W1984556901 cites W1990673708 @default.
• W1984556901 cites W1997637601 @default.
• W1984556901 cites W1998584078 @default.
• W1984556901 cites W2005212871 @default.
• W1984556901 cites W2013175365 @default.
• W1984556901 cites W2028840036 @default.
• W1984556901 cites W2035808396 @default.
• W1984556901 cites W2041794561 @default.
• W1984556901 cites W2046007618 @default.
• W1984556901 cites W2049151832 @default.
• W1984556901 cites W2051958752 @default.
• W1984556901 cites W2062036553 @default.
• W1984556901 cites W2064566965 @default.
• W1984556901 cites W2067119870 @default.
• W1984556901 cites W2071479919 @default.
• W1984556901 cites W2073463324 @default.
• W1984556901 cites W2073559873 @default.
• W1984556901 cites W2076814467 @default.
• W1984556901 cites W2082456912 @default.
• W1984556901 cites W2083036581 @default.
• W1984556901 cites W2101805877 @default.
• W1984556901 cites W2120726212 @default.
• W1984556901 cites W2134476556 @default.
• W1984556901 cites W2139716468 @default.
• W1984556901 cites W2141100025 @default.
• W1984556901 cites W2152617843 @default.
• W1984556901 cites W2470731951 @default.
• W1984556901 cites W4254616202 @default.
• W1984556901 doi "https://doi.org/10.3109/08820139709088545" @default.
• W1984556901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9399104" @default.
• W1984556901 hasPublicationYear "1997" @default.
• W1984556901 type Work @default.
• W1984556901 sameAs 1984556901 @default.
• W1984556901 citedByCount "22" @default.
• W1984556901 countsByYear W19845569012012 @default.
• W1984556901 countsByYear W19845569012013 @default.
• W1984556901 crossrefType "journal-article" @default.
• W1984556901 hasAuthorship W1984556901A5075819866 @default.
• W1984556901 hasAuthorship W1984556901A5087150619 @default.
• W1984556901 hasAuthorship W1984556901A5089132962 @default.
• W1984556901 hasConcept C153911025 @default.
• W1984556901 hasConcept C170493617 @default.
• W1984556901 hasConcept C175969161 @default.
• W1984556901 hasConcept C185592680 @default.
• W1984556901 hasConcept C203014093 @default.
• W1984556901 hasConcept C2776042228 @default.
• W1984556901 hasConcept C2777037409 @default.
• W1984556901 hasConcept C49039625 @default.
• W1984556901 hasConcept C49773422 @default.
• W1984556901 hasConcept C49802076 @default.
• W1984556901 hasConcept C54166955 @default.
• W1984556901 hasConcept C55493867 @default.
• W1984556901 hasConcept C80631254 @default.
• W1984556901 hasConcept C86803240 @default.
• W1984556901 hasConcept C88675164 @default.
• W1984556901 hasConcept C98274493 @default.
• W1984556901 hasConceptScore W1984556901C153911025 @default.
• W1984556901 hasConceptScore W1984556901C170493617 @default.
• W1984556901 hasConceptScore W1984556901C175969161 @default.
• W1984556901 hasConceptScore W1984556901C185592680 @default.
• W1984556901 hasConceptScore W1984556901C203014093 @default.
• W1984556901 hasConceptScore W1984556901C2776042228 @default.
• W1984556901 hasConceptScore W1984556901C2777037409 @default.
• W1984556901 hasConceptScore W1984556901C49039625 @default.
• W1984556901 hasConceptScore W1984556901C49773422 @default.
• W1984556901 hasConceptScore W1984556901C49802076 @default.
• W1984556901 hasConceptScore W1984556901C54166955 @default.
• W1984556901 hasConceptScore W1984556901C55493867 @default.
• W1984556901 hasConceptScore W1984556901C80631254 @default.
• W1984556901 hasConceptScore W1984556901C86803240 @default.
• W1984556901 hasConceptScore W1984556901C88675164 @default.
• W1984556901 hasConceptScore W1984556901C98274493 @default.
• W1984556901 hasIssue "5-7" @default.
• W1984556901 hasLocation W19845569011 @default.
• W1984556901 hasLocation W19845569012 @default.
• W1984556901 hasOpenAccess W1984556901 @default.

• next