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- W1984562397 abstract "ABSTRACT To the Editor.— Metastatic calcification occurs in patients with hypercalcemia of diverse etiologies. Ectopic calcification has been documented in patients with long-standing hypercalcemia without specific treatment and in patients with hypercalcemia who have been receiving prolonged phosphate therapy. However, the exact mechanism of pathogenesis of metastatic calcification is not yet clear. A working hypothesis has been proposed based on animal and human data (Lancet 1:590,1972; Chest 61:190, 1972). The hypothesis in essence tells that under normal conditions, the body keeps the serum calcium and phosphorus level in homeostasis so that their solubility product does not exceed the point beyond which they exist in solid phase. Whenever there is imbalance of serum calcium or phosphorus, or both, the solubility product of calcium phosphate is exceeded beyond the normal value (about 2.6 × 10-30) resulting in formation of colloidal particles of calcium phosphate in the blood (J Nucl Med 12:347,1971). These" @default.
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- W1984562397 date "1972-11-20" @default.
- W1984562397 modified "2023-09-27" @default.
- W1984562397 title "Calcium Phosphate Colloid: Possible Nidus for Metastatic Calcification In Hypercalcemia" @default.
- W1984562397 doi "https://doi.org/10.1001/jama.1972.03210080141032" @default.
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