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- W1984574997 abstract "Capsular contracture is the most common complication following breast augmentation or reconstruction with implants. We recently demonstrated that bone marrow-derived cells provide fibroblasts to murine skin during wound healing. To determine if bone marrow-derived cells were the cellular source of periprosthetic capsules, we created chimeric C57BL mice containing bone marrow cells from isogeneic enhanced green fluorescent protein (EGFP) mice and implanted with a textured silicone shell implant. We found that none of the mice developed infection or capsular contracture, but day 30 capsules were composed of 26.4 +/- 6.1% EGFP cells, and day 60 capsules had 21.8 +/- 10.3% EGFP cells. Immunohistochemistry revealed a small population of EGFP cells in the capsules that were myofibroblasts. Thus, breast implant capsules are partially composed of bone marrow-derived cells and, given the potential of these cells to become myofibroblasts, may explain the cellular source of capsular contracture when it develops." @default.
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- W1984574997 date "2007-04-01" @default.
- W1984574997 modified "2023-09-26" @default.
- W1984574997 title "Breast Implant Capsules Are Partially Composed of Bone Marrow–Derived Cells" @default.
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- W1984574997 doi "https://doi.org/10.1097/01.sap.0000243996.37786.4a" @default.
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