FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984577233> ?p ?o ?g. }

• W1984577233 endingPage "6427" @default.
• W1984577233 startingPage "6422" @default.
• W1984577233 abstract "Collagen is an integral part of many types of connective tissue in animals, especially skin, bones, cartilage, and basement membranes. A fibrous protein, collagen has a triple-helical structure, which is comprised of strands with a repeating Xaa-Yaa-Gly sequence. l-Proline (Pro) and 4(R)-hydroxy-l-proline (4-Hyp) residues occur most often in the Xaa and Yaa positions. The 4-Hyp residue is known to increase markedly the conformational stability of a collagen triple helix. In natural collagen, a 3(S)-hydroxy-l-proline (3-Hyp) residue occurs in the sequence: 3-Hyp-4-Hyp-Gly. Its effect on collagen stability is unknown. Here, two host−guest peptides containing 3-Hyp are synthesized: (Pro-4-Hyp-Gly)3-3-Hyp-4-Hyp-Gly-(Pro-4-Hyp-Gly)3 (peptide 1) and (Pro-4-Hyp-Gly)3-Pro-3-Hyp-Gly-(Pro-4-Hyp-Gly)3 (peptide 2). The 3-Hyp residues in these two peptides diminish triple-helical stability in comparison to Pro. This destabilization is small when 3-Hyp is in the natural Xaa position (peptide 1). There, the inductive effect of its 3-hydroxyl group diminishes slightly the strength of the interstrand 3-HypCO···HNGly hydrogen bond. The destabilization is large when 3-Hyp is in the nonnatural Yaa position (peptide 2). There, its pyrrolidine ring pucker leads to inappropriate mainchain dihedral angles and interstrand steric clashes. Thus, the natural regioisomeric residues 3-Hyp and 4-Hyp have distinct effects on the conformational stability of the collagen triple helix." @default.
• W1984577233 created "2016-06-24" @default.
• W1984577233 creator A5019213891 @default.
• W1984577233 creator A5035937977 @default.
• W1984577233 creator A5040701048 @default.
• W1984577233 creator A5060391785 @default.
• W1984577233 date "2003-04-30" @default.
• W1984577233 modified "2023-09-27" @default.
• W1984577233 title "Effect of 3-Hydroxyproline Residues on Collagen Stability" @default.
• W1984577233 cites W1583044237 @default.
• W1984577233 cites W1645361893 @default.
• W1984577233 cites W1967550539 @default.
• W1984577233 cites W1970087440 @default.
• W1984577233 cites W1976517132 @default.
• W1984577233 cites W1979221090 @default.
• W1984577233 cites W1980790511 @default.
• W1984577233 cites W1998837410 @default.
• W1984577233 cites W2004347556 @default.
• W1984577233 cites W2021798993 @default.
• W1984577233 cites W2026786922 @default.
• W1984577233 cites W2073670698 @default.
• W1984577233 cites W2078895436 @default.
• W1984577233 cites W2079946015 @default.
• W1984577233 cites W2087931197 @default.
• W1984577233 cites W2088418501 @default.
• W1984577233 cites W2097707959 @default.
• W1984577233 cites W2107878103 @default.
• W1984577233 cites W2113118331 @default.
• W1984577233 cites W2145165079 @default.
• W1984577233 cites W2313038122 @default.
• W1984577233 doi "https://doi.org/10.1021/ja034015j" @default.
• W1984577233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12785781" @default.
• W1984577233 hasPublicationYear "2003" @default.
• W1984577233 type Work @default.
• W1984577233 sameAs 1984577233 @default.
• W1984577233 citedByCount "122" @default.
• W1984577233 countsByYear W19845772332012 @default.
• W1984577233 countsByYear W19845772332013 @default.
• W1984577233 countsByYear W19845772332014 @default.
• W1984577233 countsByYear W19845772332015 @default.
• W1984577233 countsByYear W19845772332016 @default.
• W1984577233 countsByYear W19845772332017 @default.
• W1984577233 countsByYear W19845772332018 @default.
• W1984577233 countsByYear W19845772332019 @default.
• W1984577233 countsByYear W19845772332020 @default.
• W1984577233 countsByYear W19845772332021 @default.
• W1984577233 countsByYear W19845772332022 @default.
• W1984577233 countsByYear W19845772332023 @default.
• W1984577233 crossrefType "journal-article" @default.
• W1984577233 hasAuthorship W1984577233A5019213891 @default.
• W1984577233 hasAuthorship W1984577233A5035937977 @default.
• W1984577233 hasAuthorship W1984577233A5040701048 @default.
• W1984577233 hasAuthorship W1984577233A5060391785 @default.
• W1984577233 hasConcept C10919887 @default.
• W1984577233 hasConcept C109300003 @default.
• W1984577233 hasConcept C155181932 @default.
• W1984577233 hasConcept C185592680 @default.
• W1984577233 hasConcept C201194858 @default.
• W1984577233 hasConcept C2776760561 @default.
• W1984577233 hasConcept C2778851528 @default.
• W1984577233 hasConcept C2779281246 @default.
• W1984577233 hasConcept C2779797417 @default.
• W1984577233 hasConcept C2779815552 @default.
• W1984577233 hasConcept C2781338088 @default.
• W1984577233 hasConcept C515207424 @default.
• W1984577233 hasConcept C55493867 @default.
• W1984577233 hasConcept C71240020 @default.
• W1984577233 hasConceptScore W1984577233C10919887 @default.
• W1984577233 hasConceptScore W1984577233C109300003 @default.
• W1984577233 hasConceptScore W1984577233C155181932 @default.
• W1984577233 hasConceptScore W1984577233C185592680 @default.
• W1984577233 hasConceptScore W1984577233C201194858 @default.
• W1984577233 hasConceptScore W1984577233C2776760561 @default.
• W1984577233 hasConceptScore W1984577233C2778851528 @default.
• W1984577233 hasConceptScore W1984577233C2779281246 @default.
• W1984577233 hasConceptScore W1984577233C2779797417 @default.
• W1984577233 hasConceptScore W1984577233C2779815552 @default.
• W1984577233 hasConceptScore W1984577233C2781338088 @default.
• W1984577233 hasConceptScore W1984577233C515207424 @default.
• W1984577233 hasConceptScore W1984577233C55493867 @default.
• W1984577233 hasConceptScore W1984577233C71240020 @default.
• W1984577233 hasIssue "21" @default.
• W1984577233 hasLocation W19845772331 @default.
• W1984577233 hasLocation W19845772332 @default.
• W1984577233 hasOpenAccess W1984577233 @default.
• W1984577233 hasPrimaryLocation W19845772331 @default.
• W1984577233 hasRelatedWork W1600019177 @default.
• W1984577233 hasRelatedWork W1968324625 @default.
• W1984577233 hasRelatedWork W1984577233 @default.
• W1984577233 hasRelatedWork W1991820906 @default.
• W1984577233 hasRelatedWork W2039130480 @default.
• W1984577233 hasRelatedWork W2039794143 @default.
• W1984577233 hasRelatedWork W2073721795 @default.
• W1984577233 hasRelatedWork W2166410236 @default.
• W1984577233 hasRelatedWork W2727642709 @default.
• W1984577233 hasRelatedWork W4293060508 @default.
• W1984577233 hasVolume "125" @default.
• W1984577233 isParatext "false" @default.

• next