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• W1984607777 abstract "Using double-label ultrastructural immunocytochemistry, we found the synaptic input to gonadotropin-releasing hormone (GnRH) neurons in the preoptic area of aged (20 months old), virgin, male Sprague-Dawley rats to be denser than that in young adults (3 months old). These results confirmed earlier observations on F-344 virgin male rats. The aging F-344 rat, however, is prone to testicular tumor and so it was essential to see if the phenomenon was reproducible in another rat strain. In the first study, a portion of the increase in synaptic density was due to an increase in the proportion of synapses containing pleiomorphic vesicles, frequently associated with the neurotransmitter GABA. We tested the possibility directly using a double-label protocol for GnRH and glutamic acid decarboxylase (GAD). However, in the present study the density of input by GABA did not change with age. This inhibitory amino acid represented about 10% of the total innervation in young animals; but, in aged animals, because the total synaptic input was greater, GABA represented only about 4% of the innervation. Synaptic vesicles within GAD-immunoreactive terminals were uniformly clear and spherical, suggesting that pleiomorphic vesicle shape is not an appropriate criterion for GABAergic innervation." @default.
• W1984607777 created "2016-06-24" @default.
• W1984607777 creator A5018959390 @default.
• W1984607777 date "1992-11-01" @default.
• W1984607777 modified "2023-10-14" @default.
• W1984607777 title "Increased synaptic input to gonadotropin-releasing hormone neurons in aged, virgin, male sprague-dawley rats" @default.
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• W1984607777 doi "https://doi.org/10.1016/0197-4580(92)90090-k" @default.
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