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- W1984629051 abstract "The serotonin (5-HT) content of enterochromaffin cells (EC) was studied by a cytofluorimetric method in biopsies from rat duodenal mucosa after in vitro incubation with different adrenoceptor agonists and antagonists and acetylcholine (ACh). Noradrenaline (NA), Adrenaline (A) and Isoprenaline (IP) caused a decrease of 5-HT in EC down to 40–60% and for NA and A this effect was concentration-dependent. The effect was antagonized by d,1-propranolol but not by d-propranolol, metoprolol, phentolamine or phenoxy-benzamine indicating that the 5-HT release from EC is probably mediated via a true β-adrenoceptor mechanism possibly of the β2 type. ACh also decreased the 5-HT content of EC but was much less potent than the adrenergic substances. Dopamine (DA) had no effect." @default.
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- W1984629051 date "1978-06-01" @default.
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- W1984629051 title "The release of serotonin from rat duodenal enterochromaffin cells by adrenoceptor agonists studied in vitro" @default.
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- W1984629051 doi "https://doi.org/10.1111/j.1748-1716.1978.tb06209.x" @default.
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