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• W1984641863 abstract "Abstract Mouse embryo limb bud (LB) and midbrain (MB) cells were prepared from day 10 mouse embryos and cultured as micromass cell islands for 5 days. Differentiation was determined by the number of stainable foci of differentiated cells, and the concentration at which each compound inhibited the formation of differentiated foci by 50% of the control value (IC50) was estimated according to the method by Flint and Orton (1984). The values of IC50 of L-dopa, which is known as a teratogen, were 24 μig/ml in LB cultures and 12 μ/ml in MB cultures, respectively. Teratogenic hazards of three mycotoxins were compared in this system. Chaetochromin A and chaetochromin D, which were new naphtho-γ-pyrone dimers produced by Chaetomium sp., indicated strong inhibition (IC50 0.13-0.24 μ/ml) in LB and MB cell cultures, and ustilaginoidin A, which was a naphtho-γ-pyrone dimer produced by Ustilaginoidea virens, inhibited at higher concentration than chaetochromins by several-folds in LB and MB cultures." @default.
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• W1984641863 date "1987-09-01" @default.
• W1984641863 modified "2023-09-27" @default.
• W1984641863 title "Effect of Chaetochromin A, Chaetochromin D and Ustilaginoidin A, Bis (naphtho-γ-pyrone) Derivatives, on the Mouse Embryo Limb Bud and Midbrain Cells in Culture" @default.
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• W1984641863 doi "https://doi.org/10.1111/j.1741-4520.1987.tb00707.x" @default.
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