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- W1984656947 abstract "Much interest has been focused on the role of the immune system in bone remodeling. Here, we compare the production of Interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) by peripheral blood mononuclear cells (PBMC) in elderly Paget's patients, elderly osteoporotic patients and in normal elderly subjects. We studied Paget's patients (71.00 +/- 3.74 years), 7 osteoporotic patients (71.86 +/- 3.23 years), age and sex matched, and 5 elderly healthy control subjects (74.20 +/- 4.10 years) An ELISA test was used to quantify IL-1 beta and IL-6 in the supernatant culture of PBMC stimulated by phytohemagglutinin (PHA). IL-1 beta and IL-6 production from Paget's patients (IL-1 beta, 651.43 +/- 95.92 pg/ml; IL-6, 1402.85 +/- 148.11 pg/ml) was not statistically different from the production observed in the osteoporotic patients (IL-1 beta, 552.57 +/- 79.04 pg/ml; IL-6, 1458.85 +/- 118.35 pg/ml) and in the healthy elderly group (IL-1 beta, 717.60 +/- 131.34 pg/ml; IL-6, 1502.40 +/- 211.90 pg/ml). Although IL-1 and IL-6 can be involved in the bone remodeling process, we did not find any difference when we compared their production by PBMC in elderly normal, elderly osteoporotic and elderly Paget's patients." @default.
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- W1984656947 date "1997-03-01" @default.
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- W1984656947 title "Does the secretion of cytokines in the periphery reflect their role in bone metabolic diseases?" @default.
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- W1984656947 doi "https://doi.org/10.1016/s0047-6374(96)01844-1" @default.
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