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- W1984668606 abstract "We report immunohistochemical staining results for cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 in primary tumors of 117 patients with resected adenocarcinoma of the lung (median follow-up, 20 months). For COX-2, we graded the degree of tumor staining according to the sum of staining intensity and the proportion of cells staining. For MMP-9, we used morphometry to quantify cytoplasmic staining. We used the Cox proportional hazards model to analyze overall survival. With only 29 patients censored at last follow-up, after controlling for the effect of pathologic stage, staining for COX-2 and MMP-9 and subtype of tumor were related significantly to survival (P < 6 x 10(-5)). The effects of COX-2 and MMP-9 were opposite. Whereas any staining for COX-2 decreased the hazard and increased survival time, increased staining for MMP-9 increased the hazard and decreased survival time. The results also suggested that staining for COX-2 decreases with dedifferentiation. Our results suggest that staining for the combination of COX-2 and MMP-9 and categorizing tumors into papillary and nonpapillary types may provide important prognostic information for patients with resected adenocarcinoma of the lung; it is possible that these 3 variables could aid decisions about postoperative adjuvant treatment." @default.
- W1984668606 created "2016-06-24" @default.
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- W1984668606 date "2004-01-01" @default.
- W1984668606 modified "2023-09-26" @default.
- W1984668606 title "COX-2, MMP-9, and Noguchi Classification Provide Additional Prognostic Information About Adenocarcinoma of the Lung: A Study of 117 Patients From Brazil" @default.
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- W1984668606 doi "https://doi.org/10.1309/p2cd-fgu1-u7cl-v5yr" @default.
- W1984668606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15272533" @default.
- W1984668606 hasPublicationYear "2004" @default.
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