Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984679689> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1984679689 endingPage "639" @default.
- W1984679689 startingPage "639" @default.
- W1984679689 abstract "Hirschsprung's disease (HSCR) is neonatal intestinal abnormality which derived from the faliure of enteric neural crest cells migration to hindgut during embryogenesis from 5 to 12 weeks. Currenly, the knowledge of environmental factors contributing to HSCR is still scarce. Benzophenone-3 (BP-3) is one of the most widely used UV filters, and has weak estrogen and strong anti-androgenic effects. In order to examine the effect of maternal BP-3 exposure on development of offspring and explore the potential mechanism, we conducted case and control study and in vitro study. In this work, BP-3 concertrations in maternal urine was detected by ultra-high performance liquid chromatography. Besides, we investigated the cytotoxicity and receptor tyrosine kinase (RET) expression in cells exposed to BP-3. The results showed that maternal BP-3 exposure was associated with offspring's HSCR in the population as well as inhibited migration of 293T and SH-SY5Y cells. What's more, we discovered dose–response relationship between RET expression and BP-3 exposure dose, and miR-218 and some other genes involved in SLIT2/ROBO1-miR-218-RET/PLAG1 pathway were also related to BP-3 exposure. Therefore, we deduced that BP-3 influenced cell migration via SLIT2/ROBO1-miR-218-RET/PLAG1 pathway. Our study firstly revealed the relationship between maternal BP-3 exposure and HSCR as well as its potential mechanism." @default.
- W1984679689 created "2016-06-24" @default.
- W1984679689 creator A5000848045 @default.
- W1984679689 creator A5051918818 @default.
- W1984679689 date "2011-08-01" @default.
- W1984679689 modified "2023-09-25" @default.
- W1984679689 title "Lucite polymorphe secondaire aux ultraviolets C (UVC)" @default.
- W1984679689 cites W18143721 @default.
- W1984679689 cites W2003732773 @default.
- W1984679689 cites W2091967457 @default.
- W1984679689 cites W2130189647 @default.
- W1984679689 doi "https://doi.org/10.1016/j.annder.2011.05.005" @default.
- W1984679689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21893244" @default.
- W1984679689 hasPublicationYear "2011" @default.
- W1984679689 type Work @default.
- W1984679689 sameAs 1984679689 @default.
- W1984679689 citedByCount "1" @default.
- W1984679689 countsByYear W19846796892017 @default.
- W1984679689 crossrefType "journal-article" @default.
- W1984679689 hasAuthorship W1984679689A5000848045 @default.
- W1984679689 hasAuthorship W1984679689A5051918818 @default.
- W1984679689 hasConcept C101544691 @default.
- W1984679689 hasConcept C112672928 @default.
- W1984679689 hasConcept C126322002 @default.
- W1984679689 hasConcept C126749454 @default.
- W1984679689 hasConcept C134018914 @default.
- W1984679689 hasConcept C170493617 @default.
- W1984679689 hasConcept C172680121 @default.
- W1984679689 hasConcept C196843134 @default.
- W1984679689 hasConcept C2779234561 @default.
- W1984679689 hasConcept C2908647359 @default.
- W1984679689 hasConcept C502942594 @default.
- W1984679689 hasConcept C54355233 @default.
- W1984679689 hasConcept C71924100 @default.
- W1984679689 hasConcept C86803240 @default.
- W1984679689 hasConcept C95444343 @default.
- W1984679689 hasConcept C99454951 @default.
- W1984679689 hasConceptScore W1984679689C101544691 @default.
- W1984679689 hasConceptScore W1984679689C112672928 @default.
- W1984679689 hasConceptScore W1984679689C126322002 @default.
- W1984679689 hasConceptScore W1984679689C126749454 @default.
- W1984679689 hasConceptScore W1984679689C134018914 @default.
- W1984679689 hasConceptScore W1984679689C170493617 @default.
- W1984679689 hasConceptScore W1984679689C172680121 @default.
- W1984679689 hasConceptScore W1984679689C196843134 @default.
- W1984679689 hasConceptScore W1984679689C2779234561 @default.
- W1984679689 hasConceptScore W1984679689C2908647359 @default.
- W1984679689 hasConceptScore W1984679689C502942594 @default.
- W1984679689 hasConceptScore W1984679689C54355233 @default.
- W1984679689 hasConceptScore W1984679689C71924100 @default.
- W1984679689 hasConceptScore W1984679689C86803240 @default.
- W1984679689 hasConceptScore W1984679689C95444343 @default.
- W1984679689 hasConceptScore W1984679689C99454951 @default.
- W1984679689 hasIssue "8-9" @default.
- W1984679689 hasLocation W19846796891 @default.
- W1984679689 hasLocation W19846796892 @default.
- W1984679689 hasOpenAccess W1984679689 @default.
- W1984679689 hasPrimaryLocation W19846796891 @default.
- W1984679689 hasRelatedWork W1591616590 @default.
- W1984679689 hasRelatedWork W2004424018 @default.
- W1984679689 hasRelatedWork W2009428258 @default.
- W1984679689 hasRelatedWork W2064652474 @default.
- W1984679689 hasRelatedWork W2110681150 @default.
- W1984679689 hasRelatedWork W2127828366 @default.
- W1984679689 hasRelatedWork W2500314183 @default.
- W1984679689 hasRelatedWork W2520636841 @default.
- W1984679689 hasRelatedWork W3160140598 @default.
- W1984679689 hasRelatedWork W4239714589 @default.
- W1984679689 hasVolume "138" @default.
- W1984679689 isParatext "false" @default.
- W1984679689 isRetracted "false" @default.
- W1984679689 magId "1984679689" @default.
- W1984679689 workType "article" @default.