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• W1984687624 endingPage "9423" @default.
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• W1984687624 abstract "One subfamily of guanidino group-modifying enzymes (GMEs) consists of the agmatine deiminases (AgDs). These enzymes catalyze the conversion of agmatine (decarboxylated arginine) to N-carbamoyl putrescine and ammonia. In plants, viruses, and bacteria, these enzymes are thought to be involved in energy production, biosynthesis of polyamines, and biofilm formation. In particular, we are interested in the role that this enzyme plays in pathogenic bacteria. Previously, we reported the initial kinetic characterization of the agmatine deiminase from Helicobacter pylori and described the synthesis and characterization the two most potent AgD inactivators. Herein, we have expanded our initial efforts to characterize the catalytic mechanisms of AgD from H. pylori as well as Streptococcus mutans and Porphyromonas gingivalis. Through the use of pH rate profiles, pKa measurements of the active site cysteine, solvent isotope effects, and solvent viscosity effects, we have determined that the AgDs, like PADs 1 and 4, utilize a reverse protonation mechanism." @default.
• W1984687624 created "2016-06-24" @default.
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• W1984687624 date "2010-10-12" @default.
• W1984687624 modified "2023-09-23" @default.
• W1984687624 title "Mechanistic Studies of Agmatine Deiminase from Multiple Bacterial Species" @default.
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• W1984687624 doi "https://doi.org/10.1021/bi101405y" @default.
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