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- W1984701267 abstract "The present investigation deals with morphological and certain histochemical changes that precede and accompany cataracts associated with aging in the rat. The cataracts were of two types: supranuclear (SNC) and posterior subcapsular (PSC). The initial biomicroscopie lesions, which were associated with the auterior and posterior lens suture systems, respectively, were attributed to cytological alterations of the ends of the superficial fiber cells. Cortical alterations common to both types of cataract included segmental cellular swelling, and the formation of assorted globular and multilamellar inclusions. With SNC, large multilamellar bodies corresponded to anterior sutural vacuolar opacities; while swelling and dissociation of the fiber cell bodies were associated with the formation of lamellar separations, lesions which eventually appeared in the peripheral cortex. Posterior subcapsular intercellular vacuoles, many of which developed a lamellated outer structure, were characteristic of the early form of PSC. An acid phosphataso which served as a marker for lysosomal hydrolases was demonstrated in the intercellular spaces of lenses with early forms of degeneration. The major source of the extracellular enzyme appeared to be the Golgi/lysosomal system within the epithelium and cortex, although the cortical smooth endoplasmic reticulum was not ruled out. Our studies support the concept that the swelling and degeneration of cortical fibers occurring in the initial stages of the cataracts might have been caused by intercellularly located hydrolases. The value of the aged rat lens as a model for human senile cataract was reinforced by the many similarities between the murine and human forms of the disease." @default.
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- W1984701267 date "1978-09-01" @default.
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- W1984701267 title "Cataracts in the aging rat lens. Morphology and acid phosphatase histochemistry of incipient forms" @default.
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- W1984701267 doi "https://doi.org/10.1016/0014-4835(78)90165-3" @default.
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