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- W1984704966 abstract "Radioiodination of 3-iodo-4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine (3-IPP) with iodine-125 was performed via 125 I for I isotopic exchange reaction in different organic media such as acetone, dimethyl formamide (DMF), ethanol and ethyl acetate. The reaction temperature has a great effect on the labeling yield in case of DMF or ethanol as a reaction medium. The activation energies were calculated to be 4.6 kcal/mol (19.3 kJ/mol) in case of DMF as a reaction medium without phase transfer catalyst and 3.3 kcal/mol (13.8 kJ/mol) in the presence of tetrabutyl ammonium bromide (TBAB) as a phase transfer catalyst. These values are low compared with the calculated activation energy in the case of ethanol as a reaction medium (9.2 kcal/mol (38.5 kJ/mol)). The maximum radiochemical yield of 3- 125 IPP (92%) was obtained by using 20 μL of Na 125 I (7.4 MBq (200 μCi)) in the reaction flask and then adding the mixture of 150 μL of 3-IPP (1.88 mM) and 50 μL TBAB (3 mM) at 160 °C within 5 min. The labeled product was purified by means of high pressure liquid chromatography (HPLC) to give a specific activity of 272 MBq/mmol for 3- 125 IPP." @default.
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- W1984704966 date "2010-01-01" @default.
- W1984704966 modified "2023-09-25" @default.
- W1984704966 title "Radioiodination of 3-iodo-4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine via isotopic exchange reaction" @default.
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- W1984704966 doi "https://doi.org/10.1524/ract.2010.1700" @default.
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