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- W1984733494 abstract "Tailor-made nucleases for precise genome modification, such as zinc finger or TALE nucleases, currently represent the state-of-the-art for genome editing. These nucleases combine a programmable protein module which guides the enzyme to the target site with a nuclease domain which cuts DNA at the addressed site. Reprogramming of these nucleases to cut genomes at specific locations requires major protein engineering efforts. RNA-guided DNA endonuclease Cas9 of the type II (clustered regularly interspaced short palindromic repeat) CRISPR-Cas system uses CRISPR RNA (crRNA) as a guide to locate the DNA target and the Cas9 protein to cut DNA. Easy programmability of the Cas9 endonuclease using customizable RNAs brings unprecedented flexibility and versatility for targeted genome modification. We highlight the potential of the Cas9 RNA-guided DNA endonuclease as a novel tool for genome surgery, and discuss possible constraints and future prospects." @default.
- W1984733494 created "2016-06-24" @default.
- W1984733494 creator A5001141726 @default.
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- W1984733494 date "2013-11-01" @default.
- W1984733494 modified "2023-09-25" @default.
- W1984733494 title "RNA-dependent DNA endonuclease Cas9 of the CRISPR system: Holy Grail of genome editing?" @default.
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- W1984733494 doi "https://doi.org/10.1016/j.tim.2013.09.001" @default.
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