Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984742457> ?p ?o ?g. }
- W1984742457 abstract "Aims: The Purpose of this short article is to summarize the recent developments in the genetics of normal tension glaucoma (NTG). Background: Glaucoma is one of the leading causes of irreversible blindness. Primary open-angle glaucoma (POAG) is the most common type of glaucoma in most populations and is frequently associated with elevated intraocular pressure (IOP). However, patients with POAG can also have IOP within the normal range and they are classified as having normal tension glaucoma (NTG) – most likely an independent entity. In NTG, the optic nerve head is just susceptible to normal IOP. Therefore, factors other than elevated IOP are likely to play a role in the pathogenesis of glaucoma. Although factors such as myopia, older age, vasospasm, ischemia and vascular insufficiency are indicated to be associated with the development of NTG, substantial percentage of NTG patients (21%) have a family history of glaucoma suggesting that these patients may have a genetic predisposition for developing NTG. Methodology: Using the keywords or phrases such as glaucoma, genetics, normal tension glaucoma, open-angle glaucoma and retinal ganglion cell, the literature search was carried out. Results: NTG is a genetically complex disorder and many genes have been reported to be associated with the development of glaucoma. However, none of them account for a substantial portion of patient population. A complex glaucoma pathogenesis may include interplay among several factors such as genetic, epigenetic and environmental factors. Therefore, an understanding of IOP independent mechanisms of development Review Article" @default.
- W1984742457 created "2016-06-24" @default.
- W1984742457 creator A5039096233 @default.
- W1984742457 date "2013-02-13" @default.
- W1984742457 modified "2023-09-26" @default.
- W1984742457 title "Genetic Susceptibility to Normal Tension Glaucoma (NTG)" @default.
- W1984742457 cites W101689325 @default.
- W1984742457 cites W133596747 @default.
- W1984742457 cites W147739434 @default.
- W1984742457 cites W1511524860 @default.
- W1984742457 cites W1541465832 @default.
- W1984742457 cites W1568240827 @default.
- W1984742457 cites W1607194915 @default.
- W1984742457 cites W169963234 @default.
- W1984742457 cites W170467223 @default.
- W1984742457 cites W1780796932 @default.
- W1984742457 cites W185419275 @default.
- W1984742457 cites W1966028855 @default.
- W1984742457 cites W1970897340 @default.
- W1984742457 cites W1972971823 @default.
- W1984742457 cites W1987767450 @default.
- W1984742457 cites W1987849214 @default.
- W1984742457 cites W1989399186 @default.
- W1984742457 cites W1991243739 @default.
- W1984742457 cites W1992245252 @default.
- W1984742457 cites W1994543991 @default.
- W1984742457 cites W1994562860 @default.
- W1984742457 cites W1995478328 @default.
- W1984742457 cites W1997551568 @default.
- W1984742457 cites W1998021510 @default.
- W1984742457 cites W1998919048 @default.
- W1984742457 cites W1999630856 @default.
- W1984742457 cites W2002579513 @default.
- W1984742457 cites W2005641281 @default.
- W1984742457 cites W2005725365 @default.
- W1984742457 cites W2006178227 @default.
- W1984742457 cites W2007456079 @default.
- W1984742457 cites W2010389727 @default.
- W1984742457 cites W2027673202 @default.
- W1984742457 cites W2029607802 @default.
- W1984742457 cites W2036341321 @default.
- W1984742457 cites W2038439194 @default.
- W1984742457 cites W2039768122 @default.
- W1984742457 cites W2041745041 @default.
- W1984742457 cites W2042073572 @default.
- W1984742457 cites W2045048112 @default.
- W1984742457 cites W2051550352 @default.
- W1984742457 cites W2052783288 @default.
- W1984742457 cites W2054750473 @default.
- W1984742457 cites W2055296116 @default.
- W1984742457 cites W2055487273 @default.
- W1984742457 cites W2059053771 @default.
- W1984742457 cites W2059099579 @default.
- W1984742457 cites W2065670354 @default.
- W1984742457 cites W2073873718 @default.
- W1984742457 cites W2075205619 @default.
- W1984742457 cites W2075573512 @default.
- W1984742457 cites W2077408964 @default.
- W1984742457 cites W2080570055 @default.
- W1984742457 cites W2084810632 @default.
- W1984742457 cites W2085037551 @default.
- W1984742457 cites W2094420747 @default.
- W1984742457 cites W2096630433 @default.
- W1984742457 cites W2099573670 @default.
- W1984742457 cites W2100113746 @default.
- W1984742457 cites W2101740561 @default.
- W1984742457 cites W2101873043 @default.
- W1984742457 cites W2102060212 @default.
- W1984742457 cites W2104650771 @default.
- W1984742457 cites W2104782261 @default.
- W1984742457 cites W2110897487 @default.
- W1984742457 cites W2111058826 @default.
- W1984742457 cites W2119909636 @default.
- W1984742457 cites W2120723437 @default.
- W1984742457 cites W2121189658 @default.
- W1984742457 cites W2124088771 @default.
- W1984742457 cites W2125262210 @default.
- W1984742457 cites W2129111836 @default.
- W1984742457 cites W2129319296 @default.
- W1984742457 cites W2133095706 @default.
- W1984742457 cites W2142011909 @default.
- W1984742457 cites W2142861117 @default.
- W1984742457 cites W2143189496 @default.
- W1984742457 cites W2145195065 @default.
- W1984742457 cites W2145273997 @default.
- W1984742457 cites W2151779330 @default.
- W1984742457 cites W2163275807 @default.
- W1984742457 cites W2169113983 @default.
- W1984742457 cites W2185978695 @default.
- W1984742457 cites W2285519774 @default.
- W1984742457 cites W2315775988 @default.
- W1984742457 cites W2325896885 @default.
- W1984742457 cites W2399924607 @default.
- W1984742457 cites W2917323190 @default.
- W1984742457 cites W58763518 @default.
- W1984742457 cites W947388247 @default.
- W1984742457 doi "https://doi.org/10.5281/zenodo.7899" @default.
- W1984742457 hasPublicationYear "2013" @default.
- W1984742457 type Work @default.
- W1984742457 sameAs 1984742457 @default.