FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984745692> ?p ?o ?g. }

• W1984745692 endingPage "10570" @default.
• W1984745692 startingPage "10560" @default.
• W1984745692 abstract "A large fraction of hydrogens in proteins and nucleic acids is of the methylene type. Their detailed study, however, in terms of structure and dynamics by NMR spectroscopy is hampered by their fast relaxation properties, which give rise to low sensitivity and resolution. It is demonstrated that six different relaxation interference processes, involving 1H−13C and 1H−1H dipolar interactions and 1H and 13C chemical shift anisotropy, can be used simultaneously to mitigate these problems effectively. The approach is applicable to the majority of NMR experiments commonly used to study side chain and backbone conformation. For proteins, its efficiency is evaluated quantitatively for two samples: the third IgG-binding domain from Streptococcal Protein G and the protein calmodulin complexed with a 26-residue target peptide. Gains in both resolution and sensitivity by up to factors of 3.2 and 2.0, respectively, are observed for Gly residues at high magnetic field strengths, but even at much lower fields gains remain substantial. The resolution enhancement obtained for methylene groups makes possible a detailed analysis of spectral regions commonly considered inaccessible due to spectral crowding. For DNA, the high resolution now obtainable for C5‘ sites permits an H5‘/H5‘ ‘-based sequential NOE assignment procedure, complementary to the conventional base-H1‘/H2‘/H2‘ ‘ pathway." @default.
• W1984745692 created "2016-06-24" @default.
• W1984745692 creator A5015891385 @default.
• W1984745692 creator A5024727980 @default.
• W1984745692 creator A5038347649 @default.
• W1984745692 creator A5038369681 @default.
• W1984745692 creator A5041624099 @default.
• W1984745692 creator A5082289559 @default.
• W1984745692 date "2004-08-10" @default.
• W1984745692 modified "2023-10-16" @default.
• W1984745692 title "Relaxation-Optimized NMR Spectroscopy of Methylene Groups in Proteins and Nucleic Acids" @default.
• W1984745692 cites W1554559686 @default.
• W1984745692 cites W1599450894 @default.
• W1984745692 cites W1965730551 @default.
• W1984745692 cites W1969606491 @default.
• W1984745692 cites W1982188298 @default.
• W1984745692 cites W1989487251 @default.
• W1984745692 cites W1990675281 @default.
• W1984745692 cites W1993257312 @default.
• W1984745692 cites W2002584278 @default.
• W1984745692 cites W2013225840 @default.
• W1984745692 cites W2024142216 @default.
• W1984745692 cites W2052510418 @default.
• W1984745692 cites W2053590485 @default.
• W1984745692 cites W2073486807 @default.
• W1984745692 cites W2076449291 @default.
• W1984745692 cites W2110893284 @default.
• W1984745692 cites W2134224798 @default.
• W1984745692 cites W2147281292 @default.
• W1984745692 cites W2169821755 @default.
• W1984745692 cites W2313422370 @default.
• W1984745692 cites W2327948321 @default.
• W1984745692 cites W26769549 @default.
• W1984745692 cites W312456114 @default.
• W1984745692 cites W343098988 @default.
• W1984745692 cites W4234175308 @default.
• W1984745692 cites W67546863 @default.
• W1984745692 cites W95535446 @default.
• W1984745692 doi "https://doi.org/10.1021/ja047904v" @default.
• W1984745692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15327312" @default.
• W1984745692 hasPublicationYear "2004" @default.
• W1984745692 type Work @default.
• W1984745692 sameAs 1984745692 @default.
• W1984745692 citedByCount "72" @default.
• W1984745692 countsByYear W19847456922012 @default.
• W1984745692 countsByYear W19847456922013 @default.
• W1984745692 countsByYear W19847456922014 @default.
• W1984745692 countsByYear W19847456922015 @default.
• W1984745692 countsByYear W19847456922017 @default.
• W1984745692 countsByYear W19847456922018 @default.
• W1984745692 countsByYear W19847456922019 @default.
• W1984745692 countsByYear W19847456922020 @default.
• W1984745692 countsByYear W19847456922021 @default.
• W1984745692 countsByYear W19847456922022 @default.
• W1984745692 countsByYear W19847456922023 @default.
• W1984745692 crossrefType "journal-article" @default.
• W1984745692 hasAuthorship W1984745692A5015891385 @default.
• W1984745692 hasAuthorship W1984745692A5024727980 @default.
• W1984745692 hasAuthorship W1984745692A5038347649 @default.
• W1984745692 hasAuthorship W1984745692A5038369681 @default.
• W1984745692 hasAuthorship W1984745692A5041624099 @default.
• W1984745692 hasAuthorship W1984745692A5082289559 @default.
• W1984745692 hasConcept C113196181 @default.
• W1984745692 hasConcept C116447816 @default.
• W1984745692 hasConcept C121332964 @default.
• W1984745692 hasConcept C122707536 @default.
• W1984745692 hasConcept C138268822 @default.
• W1984745692 hasConcept C147597530 @default.
• W1984745692 hasConcept C154945302 @default.
• W1984745692 hasConcept C15744967 @default.
• W1984745692 hasConcept C178790620 @default.
• W1984745692 hasConcept C185592680 @default.
• W1984745692 hasConcept C205860874 @default.
• W1984745692 hasConcept C24107716 @default.
• W1984745692 hasConcept C2776029896 @default.
• W1984745692 hasConcept C2777454769 @default.
• W1984745692 hasConcept C29688787 @default.
• W1984745692 hasConcept C32891209 @default.
• W1984745692 hasConcept C41008148 @default.
• W1984745692 hasConcept C46141821 @default.
• W1984745692 hasConcept C519063684 @default.
• W1984745692 hasConcept C55493867 @default.
• W1984745692 hasConcept C62520636 @default.
• W1984745692 hasConcept C66974803 @default.
• W1984745692 hasConcept C71240020 @default.
• W1984745692 hasConcept C77805123 @default.
• W1984745692 hasConcept C8010536 @default.
• W1984745692 hasConceptScore W1984745692C113196181 @default.
• W1984745692 hasConceptScore W1984745692C116447816 @default.
• W1984745692 hasConceptScore W1984745692C121332964 @default.
• W1984745692 hasConceptScore W1984745692C122707536 @default.
• W1984745692 hasConceptScore W1984745692C138268822 @default.
• W1984745692 hasConceptScore W1984745692C147597530 @default.
• W1984745692 hasConceptScore W1984745692C154945302 @default.
• W1984745692 hasConceptScore W1984745692C15744967 @default.
• W1984745692 hasConceptScore W1984745692C178790620 @default.
• W1984745692 hasConceptScore W1984745692C185592680 @default.
• W1984745692 hasConceptScore W1984745692C205860874 @default.

• next