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• W1984753323 abstract "As the chromophoric component of the visual pigment, retinol plays an essential role in vision. In the plasma, retinol is transported by retinol-binding protein (RBP) in complex with transthyretin (TTR, prealbumin). In previous work we demonstrated intraocular synthesis of TTR. To determine whether RBP is also synthesized in the eye, we performed Northern and Western blot analysis of rat eye, and detected both RBP mRNA and immunoreactive RBP. Regional Northern analysis of bovine eye localized RBP mRNA to ciliary body/iris and retina/RPE. Preliminary immunohistochemical studies revealed a widespread but heterogeneous distribution of RBP in rat eye. We postulate that ocular RBP and TTR are involved in the intraocular translocation of retinol." @default.
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• W1984753323 date "1988-12-01" @default.
• W1984753323 modified "2023-09-25" @default.
• W1984753323 title "Retinol-binding protein is synthesized in the mammalian eye" @default.
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• W1984753323 doi "https://doi.org/10.1016/s0006-291x(88)80984-7" @default.
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