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• W1984753812 endingPage "39" @default.
• W1984753812 startingPage "39" @default.
• W1984753812 abstract "Artemisinin from the plant Artemisia annua (A. annua) L, and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in developing countries. Traditionally, A. annua was used by the Chinese as a tea to treat fever. More recently, investigators have shown that tea infusions and oral consumption of the dried leaves of the plant have prophylactic and therapeutic efficacy. The presence of a complex matrix of chemicals within the leaves seems to enhance both the bioavailability and efficacy of artemisinin. Although about 1000-fold less potent than artemisinin in their antiplasmodial activity, these plant chemicals are mainly small molecules that include other artemisinic compounds, terpenes (mainly mono and sesqui), flavonoids, and polyphenolic acids. In addition, polysaccharide constituents of A. annua may enhance bioavailability of artemisinin. Rodent pharmacokinetics showed longer T1/2 and Tmax and greater Cmax and AUC in Plasmodium chabaudi-infected mice treated with A. annua dried leaves than in healthy mice. Pharmacokinetics of deoxyartemisinin, a liver metabolite of artemisinin, was more inhibited in infected than in healthy mice. In healthy mice, artemisinin serum levels were > 40-fold greater in dried leaf fed mice than those fed with pure artemisinin. Human trial data showed that when delivered as dried leaves, 40-fold less artemisinin was required to obtain a therapeutic response compared to pure artemisinin. ACTs are still unaffordable for many malaria patients, and cost estimates for A. annua dried leaf tablet production are orders of magnitude less than for ACT, despite improvements in the production capacity. Considering that for > 2000 years this plant was used in traditional Chinese medicine for treatment of fever with no apparent appearance of artemisinin drug resistance, the evidence argues for inclusion of affordable A. annua dried leaf tablets into the arsenal of drugs to combat malaria and other artemisinin-susceptible diseases." @default.
• W1984753812 created "2016-06-24" @default.
• W1984753812 creator A5010235941 @default.
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• W1984753812 creator A5052850066 @default.
• W1984753812 creator A5081633721 @default.
• W1984753812 creator A5091433248 @default.
• W1984753812 date "2014-01-01" @default.
• W1984753812 modified "2023-09-27" @default.
• W1984753812 title "Dried-leaf<i>Artemisia annua</i>: A practical malaria therapeutic for developing countries?" @default.
• W1984753812 cites W111833607 @default.
• W1984753812 cites W143061628 @default.
• W1984753812 cites W1510341628 @default.
• W1984753812 cites W1546275598 @default.
• W1984753812 cites W1692234463 @default.
• W1984753812 cites W1967198016 @default.
• W1984753812 cites W1970285783 @default.
• W1984753812 cites W1976919271 @default.
• W1984753812 cites W1980503801 @default.
• W1984753812 cites W1981404580 @default.
• W1984753812 cites W1982285873 @default.
• W1984753812 cites W1982842000 @default.
• W1984753812 cites W1983275249 @default.
• W1984753812 cites W1986111317 @default.
• W1984753812 cites W1990226486 @default.
• W1984753812 cites W1991072114 @default.
• W1984753812 cites W1994831480 @default.
• W1984753812 cites W1997833445 @default.
• W1984753812 cites W1998328584 @default.
• W1984753812 cites W2002720512 @default.
• W1984753812 cites W2004706439 @default.
• W1984753812 cites W2007216731 @default.
• W1984753812 cites W2009363563 @default.
• W1984753812 cites W2010067891 @default.
• W1984753812 cites W2011995987 @default.
• W1984753812 cites W2019758371 @default.
• W1984753812 cites W2025332273 @default.
• W1984753812 cites W2025894699 @default.
• W1984753812 cites W2028765375 @default.
• W1984753812 cites W2029346162 @default.
• W1984753812 cites W2029818308 @default.
• W1984753812 cites W2031962140 @default.
• W1984753812 cites W2032433680 @default.
• W1984753812 cites W2032787443 @default.
• W1984753812 cites W2034301323 @default.
• W1984753812 cites W2036702309 @default.
• W1984753812 cites W2042309157 @default.
• W1984753812 cites W2043645060 @default.
• W1984753812 cites W2043927617 @default.
• W1984753812 cites W2045037263 @default.
• W1984753812 cites W2048380602 @default.
• W1984753812 cites W2050811145 @default.
• W1984753812 cites W2051271692 @default.
• W1984753812 cites W2051752701 @default.
• W1984753812 cites W2052470569 @default.
• W1984753812 cites W2055853083 @default.
• W1984753812 cites W2059176902 @default.
• W1984753812 cites W2059645638 @default.
• W1984753812 cites W2061316164 @default.
• W1984753812 cites W2071258560 @default.
• W1984753812 cites W2072088307 @default.
• W1984753812 cites W2075718034 @default.
• W1984753812 cites W2076151477 @default.
• W1984753812 cites W2076357364 @default.
• W1984753812 cites W2078562467 @default.
• W1984753812 cites W2079560539 @default.
• W1984753812 cites W2086184346 @default.
• W1984753812 cites W2086600892 @default.
• W1984753812 cites W2088162678 @default.
• W1984753812 cites W2088440295 @default.
• W1984753812 cites W2097868923 @default.
• W1984753812 cites W2098537325 @default.
• W1984753812 cites W2100954397 @default.
• W1984753812 cites W2103021315 @default.
• W1984753812 cites W2105222535 @default.
• W1984753812 cites W2108834482 @default.
• W1984753812 cites W2108893293 @default.
• W1984753812 cites W2110367490 @default.
• W1984753812 cites W2110976989 @default.
• W1984753812 cites W2111073539 @default.
• W1984753812 cites W2112474978 @default.
• W1984753812 cites W2113934543 @default.
• W1984753812 cites W2115706256 @default.
• W1984753812 cites W2117201375 @default.
• W1984753812 cites W2118989411 @default.
• W1984753812 cites W2119451336 @default.
• W1984753812 cites W2120106015 @default.
• W1984753812 cites W2121036679 @default.
• W1984753812 cites W2121285877 @default.
• W1984753812 cites W2122202442 @default.
• W1984753812 cites W2123030025 @default.
• W1984753812 cites W2124615191 @default.
• W1984753812 cites W2126267287 @default.
• W1984753812 cites W2129126743 @default.
• W1984753812 cites W2131039021 @default.
• W1984753812 cites W2132314881 @default.
• W1984753812 cites W2135926190 @default.
• W1984753812 cites W2136040902 @default.

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