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• W1984764876 abstract "DERCHAK, P. A., J. M. STAGER, D. A. TANNER, and R. F. CHAPMAN. Expiratory flow limitation confounds ventilatory response during exercise in athletes. Med. Sci. Sports Exerc., Vol. 32, No. 11, pp. 1873–1879, 2000. Introduction A significant number of highly trained endurance runners have been observed to display an inadequate hyperventilatory response to intense exercise. Two potential mechanisms include low ventilatory responsiveness to hypoxia and ventilatory limitation as a result of maximum expiratory flow rates being achieved. Purpose To test the hypothesis that expiratory flow limitation can complicate determination of ventilatory responsiveness during exercise the following study was performed. Methods/Materials Sixteen elite male runners were categorized based on expiratory flow limitation observed in flow volume loops collected during the final minute of progressive exercise to exhaustion. Eight flow limited (FL) (V̇O2max, 75.9 ± 2.4 mL·kg−1·min−1; expiratory flow limitation, 47.3 ± 20.4%) and eight non-flow limited subjects (NFL) (V̇O2max, 75.6 ± 4.8 mL·kg−1·min−1; expiratory flow limitation, 0.3 ± 0.8%) were tested for hypoxic ventilatory responsiveness (HVR). Results Independent groups ANOVA revealed no significant differences between FL and NFL for V̇O2max, V̇E max (136.2 ± 16.0 vs 137.5 ± 21.6 L·min−1), V̇E/V̇O2 (28.4 ± 3.2 vs 27.6 ± 2.9 L·lO2−1), V̇E/V̇CO2 (24.8 ± 3.1 vs 24.4 ± 2.0 L·lCO2−1), HVR (0.2 ± 0.2 vs 0.3 ± 0.1 L·%SaO2−1), or SaO2 at max (89.1 ± 2.4 vs 86.6 ± 4.1%). A significant relationship was observed between HVR and SaO2 (r = 0.92, P ≤ 0.001) in NFL that was not present in FL. Conversely, a significant relationship between V̇E/V̇O2 and SaO2 (r = 0.79, P ≤ 0.019) was observed in FL but not NFL. Regression analysis indicated that the HVR-SaO2 and SaO2-V̇E/V̇O2 relationships differed between groups. Discussion When flow limitation is controlled for, HVR plays a more significant role in determining SaO2 in highly trained athletes than has been previously suggested." @default.
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• W1984764876 date "2000-11-01" @default.
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• W1984764876 title "Expiratory flow limitation confounds ventilatory response during exercise in athletes" @default.
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• W1984764876 doi "https://doi.org/10.1097/00005768-200011000-00009" @default.
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