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- W1984768639 abstract "In phenobarbitone-anesthetized rats the effects of interleukin 1β (IL-1β) and tumor necrosis factors (TNFs) were examined on die capsaicin-induced increase of plantar cutaneous blood flow in the rat hind paw as measured by laser Doppler flowmetry. IL-1β (0.5–500 pg) or TNFα or TNFβ (50–5000 pg) was injected subcutaneously into the left paws, while the right paws received vehicle (10 μL) only. IL-1β was without effect on blood flow by its own but dose dependency enhanced the hyperemia due to capsaicin (0.3 μg). TNFs failed to enhance the capsaicin-induced vasodilatation, although 5000 pg TNFα produced a transient increase of local blood flow. Indomethacin (10 mg/kg, i.p.) did not alter the capsaicin-induced vasodilatation but prevented IL-1β (50 pg) from augmenting the hyperemic response to capsaicin. Likewise, blockade of nitric oxide formation by N G -nitro-L-arginine methyl ester (L-NAME) failed to affect the capsaicin-evoked vasodilatation but abolished its amplification by IL-1β. Systemic pretreatment with a neurotoxic dose of capsaicin reduced the capsaicin-induced hyperemia and prevented the facilitatory effect of IL-1β. The hyperemia evoked by intraplantar calcitonin gene related peptide (0.038–3.8 ng) was not altered by IL-1β (50 pg). These data indicate that IL-1β but not TNF enhances the cutaneous hyperemic response to capsaicin. This proinflammatory action arises from sensitization of afferent nerve endings and depends on nitric oxide and cyclooxygenase products as essential intermediates.Key words: interleukin 1β, tumor necrosis factor, capsaicin, neurogenic inflammation, nitric oxide." @default.
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- W1984768639 date "1995-07-01" @default.
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- W1984768639 title "Interleukin 1β, but not tumor necrosis factor, enhances neurogenic vasodilatation in the rat skin: involvement of nitric oxide" @default.
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- W1984768639 doi "https://doi.org/10.1139/y95-153" @default.
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