Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984769441> ?p ?o ?g. }
- W1984769441 endingPage "e981483" @default.
- W1984769441 startingPage "e981483" @default.
- W1984769441 abstract "Clinical studies investigating the impact of natural killer (NK) cells in allogeneic hematopoietic stem cell transplantation settings have yielded promising results. However, NK cells are a functionally and phenotypically heterogeneous population. Therefore, we addressed the functional relevance of specific NK cell subsets distinguished by expression of CD117, CD27 and CD11b surface markers in graft-versus-leukemia (GVL)-reaction and graft-versus-host-disease (GVHD). Our results clearly demonstrate that the subset of c-Kit−CD27−CD11b+ NK cells expressed multiple cytotoxic pathway genes and provided optimal graft-versus-leukemia-effects, while significantly reducing T cell proliferation induced by allogeneic dendritic cells. Furthermore, these NK cells migrated to inflamed intestinal tissues where graft-versus-host-colitis was efficiently mitigated. For the first time, we identified the c-Kit−CD27−CD11b+ NK cell population as the specific effector NK cell subset capable of significantly diminishing GVHD in fully mismatched bone marrow transplantation settings. In conclusion, the subset of c-Kit−CD27−CD11b+ NK cells not only supports GVL, but also plays a unique role in the protection against GVHD by migrating to the peripheral GVHD target organs where they exert efficient immunoregulatory activities. These new insights demonstrate the importance of selecting the optimal NK cell subset for cellular immunotherapy following allogeneic hematopoietic stem cell transplantation." @default.
- W1984769441 created "2016-06-24" @default.
- W1984769441 creator A5019770680 @default.
- W1984769441 creator A5026973115 @default.
- W1984769441 creator A5027256584 @default.
- W1984769441 creator A5027340443 @default.
- W1984769441 creator A5029095694 @default.
- W1984769441 creator A5032832082 @default.
- W1984769441 creator A5033412803 @default.
- W1984769441 creator A5040596626 @default.
- W1984769441 creator A5041517574 @default.
- W1984769441 creator A5043255569 @default.
- W1984769441 creator A5053584251 @default.
- W1984769441 creator A5062175150 @default.
- W1984769441 creator A5067360252 @default.
- W1984769441 creator A5067838239 @default.
- W1984769441 creator A5069434242 @default.
- W1984769441 creator A5081701091 @default.
- W1984769441 creator A5081818015 @default.
- W1984769441 creator A5084803299 @default.
- W1984769441 creator A5090339272 @default.
- W1984769441 date "2015-01-02" @default.
- W1984769441 modified "2023-09-23" @default.
- W1984769441 title "Identification and characterization of the specific murine NK cell subset supporting graft-<i>versus</i>-leukemia- and reducing graft-<i>versus</i>-host-effects" @default.
- W1984769441 cites W1488000330 @default.
- W1984769441 cites W1528382674 @default.
- W1984769441 cites W1544331058 @default.
- W1984769441 cites W1798184081 @default.
- W1984769441 cites W1892222275 @default.
- W1984769441 cites W1966315835 @default.
- W1984769441 cites W1968139996 @default.
- W1984769441 cites W1984515197 @default.
- W1984769441 cites W1992908671 @default.
- W1984769441 cites W1998504569 @default.
- W1984769441 cites W2008992933 @default.
- W1984769441 cites W2010438746 @default.
- W1984769441 cites W2034286815 @default.
- W1984769441 cites W2042149494 @default.
- W1984769441 cites W2049024742 @default.
- W1984769441 cites W2050752994 @default.
- W1984769441 cites W2055422992 @default.
- W1984769441 cites W2067308312 @default.
- W1984769441 cites W2070692395 @default.
- W1984769441 cites W2079241332 @default.
- W1984769441 cites W2086425322 @default.
- W1984769441 cites W2088851866 @default.
- W1984769441 cites W2090858884 @default.
- W1984769441 cites W2092215629 @default.
- W1984769441 cites W2092235636 @default.
- W1984769441 cites W2096449627 @default.
- W1984769441 cites W2106943429 @default.
- W1984769441 cites W2147068163 @default.
- W1984769441 cites W2158217645 @default.
- W1984769441 cites W2164280295 @default.
- W1984769441 cites W2164296311 @default.
- W1984769441 cites W2165635676 @default.
- W1984769441 cites W2165813814 @default.
- W1984769441 cites W2171945667 @default.
- W1984769441 doi "https://doi.org/10.4161/2162402x.2014.981483" @default.
- W1984769441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4368119" @default.
- W1984769441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25949862" @default.
- W1984769441 hasPublicationYear "2015" @default.
- W1984769441 type Work @default.
- W1984769441 sameAs 1984769441 @default.
- W1984769441 citedByCount "34" @default.
- W1984769441 countsByYear W19847694412016 @default.
- W1984769441 countsByYear W19847694412017 @default.
- W1984769441 countsByYear W19847694412018 @default.
- W1984769441 countsByYear W19847694412019 @default.
- W1984769441 countsByYear W19847694412020 @default.
- W1984769441 countsByYear W19847694412021 @default.
- W1984769441 countsByYear W19847694412022 @default.
- W1984769441 countsByYear W19847694412023 @default.
- W1984769441 crossrefType "journal-article" @default.
- W1984769441 hasAuthorship W1984769441A5019770680 @default.
- W1984769441 hasAuthorship W1984769441A5026973115 @default.
- W1984769441 hasAuthorship W1984769441A5027256584 @default.
- W1984769441 hasAuthorship W1984769441A5027340443 @default.
- W1984769441 hasAuthorship W1984769441A5029095694 @default.
- W1984769441 hasAuthorship W1984769441A5032832082 @default.
- W1984769441 hasAuthorship W1984769441A5033412803 @default.
- W1984769441 hasAuthorship W1984769441A5040596626 @default.
- W1984769441 hasAuthorship W1984769441A5041517574 @default.
- W1984769441 hasAuthorship W1984769441A5043255569 @default.
- W1984769441 hasAuthorship W1984769441A5053584251 @default.
- W1984769441 hasAuthorship W1984769441A5062175150 @default.
- W1984769441 hasAuthorship W1984769441A5067360252 @default.
- W1984769441 hasAuthorship W1984769441A5067838239 @default.
- W1984769441 hasAuthorship W1984769441A5069434242 @default.
- W1984769441 hasAuthorship W1984769441A5081701091 @default.
- W1984769441 hasAuthorship W1984769441A5081818015 @default.
- W1984769441 hasAuthorship W1984769441A5084803299 @default.
- W1984769441 hasAuthorship W1984769441A5090339272 @default.
- W1984769441 hasBestOaLocation W19847694411 @default.
- W1984769441 hasConcept C126322002 @default.
- W1984769441 hasConcept C129374314 @default.
- W1984769441 hasConcept C154317977 @default.
- W1984769441 hasConcept C202751555 @default.