FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984777316> ?p ?o ?g. }

• W1984777316 endingPage "6453" @default.
• W1984777316 startingPage "6444" @default.
• W1984777316 abstract "Direct intramyocardial injection of the desired cell types in a dissociated form is a common route of cell transplantation for repair of damaged myocardium. However, following injection of dissociated cells, a massive loss of transplanted cells has been reported. In this study, human amniotic fluid stem cells (hAFSCs) were used as the cell source for the fabrication of cell sheet fragments, using a thermo-responsive methylcellulose hydrogel system. The fabricated hAFSC sheet fragments preserved the endogenous extracellular matrices (ECM) and retained their cell phenotype. Test samples were xenogenically transplanted into the peri-ischemic area of an immune-suppressed rat model at 1 week after myocardial infarction (MI) induction. There were four treatment groups (n>=10): sham; saline; dissociated hAFSCs; and hAFSC sheet fragments. The results obtained in the echocardiography revealed that the group treated with hAFSC sheet fragments had a superior heart function to those treated with saline or dissociated hAFSCs. Due to their inherent ECM, hAFSC sheet fragments had a better ability of cell retention and proliferation than dissociated hAFSCs upon transplantation to the host myocardium. Additionally, transplantation of hAFSC sheet fragments stimulated a significant increase in vascular density, consequently contributing towards improved wall thickness and a reduction in the infarct size, when compared with dissociated hAFSCs. Our histological findings and qPCR analyses suggest that the transplanted hAFSCs can be differentiated into cardiomyocyte-like cells and cells of endothelial lineages and modulate expression of multiple angiogenic cytokines and cardiac protective factor with the potential to promote neo-vascularization, which evidently contributed to the improvement of ventricular function." @default.
• W1984777316 created "2016-06-24" @default.
• W1984777316 creator A5000263825 @default.
• W1984777316 creator A5006890879 @default.
• W1984777316 creator A5008387139 @default.
• W1984777316 creator A5022567517 @default.
• W1984777316 creator A5033841853 @default.
• W1984777316 creator A5036237895 @default.
• W1984777316 creator A5044739073 @default.
• W1984777316 creator A5057309708 @default.
• W1984777316 creator A5081606815 @default.
• W1984777316 creator A5082801152 @default.
• W1984777316 creator A5085025165 @default.
• W1984777316 date "2010-09-01" @default.
• W1984777316 modified "2023-10-14" @default.
• W1984777316 title "Cardiac repair with injectable cell sheet fragments of human amniotic fluid stem cells in an immune-suppressed rat model" @default.
• W1984777316 cites W160130927 @default.
• W1984777316 cites W1631250427 @default.
• W1984777316 cites W1963810813 @default.
• W1984777316 cites W1963995886 @default.
• W1984777316 cites W1965863460 @default.
• W1984777316 cites W1968154437 @default.
• W1984777316 cites W1968494621 @default.
• W1984777316 cites W1968853121 @default.
• W1984777316 cites W1974915473 @default.
• W1984777316 cites W2010319438 @default.
• W1984777316 cites W2016028273 @default.
• W1984777316 cites W2025764784 @default.
• W1984777316 cites W2032921899 @default.
• W1984777316 cites W2041088020 @default.
• W1984777316 cites W2041308307 @default.
• W1984777316 cites W2041703442 @default.
• W1984777316 cites W2044921885 @default.
• W1984777316 cites W2054241011 @default.
• W1984777316 cites W2062847462 @default.
• W1984777316 cites W2069940803 @default.
• W1984777316 cites W2076134714 @default.
• W1984777316 cites W2081433223 @default.
• W1984777316 cites W2086409087 @default.
• W1984777316 cites W2087419032 @default.
• W1984777316 cites W2088753356 @default.
• W1984777316 cites W2091395040 @default.
• W1984777316 cites W2098849525 @default.
• W1984777316 cites W2098892229 @default.
• W1984777316 cites W2116446546 @default.
• W1984777316 cites W2118837137 @default.
• W1984777316 cites W2120839900 @default.
• W1984777316 cites W2127738960 @default.
• W1984777316 cites W2155758569 @default.
• W1984777316 cites W2160293700 @default.
• W1984777316 cites W2165438231 @default.
• W1984777316 cites W23495578 @default.
• W1984777316 doi "https://doi.org/10.1016/j.biomaterials.2010.04.069" @default.
• W1984777316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20621766" @default.
• W1984777316 hasPublicationYear "2010" @default.
• W1984777316 type Work @default.
• W1984777316 sameAs 1984777316 @default.
• W1984777316 citedByCount "71" @default.
• W1984777316 countsByYear W19847773162012 @default.
• W1984777316 countsByYear W19847773162013 @default.
• W1984777316 countsByYear W19847773162014 @default.
• W1984777316 countsByYear W19847773162015 @default.
• W1984777316 countsByYear W19847773162016 @default.
• W1984777316 countsByYear W19847773162017 @default.
• W1984777316 countsByYear W19847773162018 @default.
• W1984777316 countsByYear W19847773162019 @default.
• W1984777316 countsByYear W19847773162020 @default.
• W1984777316 countsByYear W19847773162021 @default.
• W1984777316 countsByYear W19847773162022 @default.
• W1984777316 countsByYear W19847773162023 @default.
• W1984777316 crossrefType "journal-article" @default.
• W1984777316 hasAuthorship W1984777316A5000263825 @default.
• W1984777316 hasAuthorship W1984777316A5006890879 @default.
• W1984777316 hasAuthorship W1984777316A5008387139 @default.
• W1984777316 hasAuthorship W1984777316A5022567517 @default.
• W1984777316 hasAuthorship W1984777316A5033841853 @default.
• W1984777316 hasAuthorship W1984777316A5036237895 @default.
• W1984777316 hasAuthorship W1984777316A5044739073 @default.
• W1984777316 hasAuthorship W1984777316A5057309708 @default.
• W1984777316 hasAuthorship W1984777316A5081606815 @default.
• W1984777316 hasAuthorship W1984777316A5082801152 @default.
• W1984777316 hasAuthorship W1984777316A5085025165 @default.
• W1984777316 hasConcept C12554922 @default.
• W1984777316 hasConcept C126322002 @default.
• W1984777316 hasConcept C136229726 @default.
• W1984777316 hasConcept C1491633281 @default.
• W1984777316 hasConcept C185592680 @default.
• W1984777316 hasConcept C189165786 @default.
• W1984777316 hasConcept C192562407 @default.
• W1984777316 hasConcept C198826908 @default.
• W1984777316 hasConcept C203014093 @default.
• W1984777316 hasConcept C2778849806 @default.
• W1984777316 hasConcept C28328180 @default.
• W1984777316 hasConcept C28406088 @default.
• W1984777316 hasConcept C2911091166 @default.
• W1984777316 hasConcept C55493867 @default.
• W1984777316 hasConcept C71924100 @default.
• W1984777316 hasConcept C86803240 @default.

• next