Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984786163> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1984786163 endingPage "19" @default.
- W1984786163 startingPage "13" @default.
- W1984786163 abstract "Supernumerary ring chromosomes and/or giant marker chromosomes are often seen in soft-tissue tumors of low-grade or borderline malignancy, such as well-differentiated liposarcomas or atypical lipomas. Classic cytogenetic banding techniques have proved insufficient to identify the genomic composition and structure of such rings and markers, but fluorescent in situ hybridization (FISH) studies have shown that they consist mainly of amplified material from chromosome 12, more specifically from bands 12q13→q15. We have used the new FISH-based screening techniques comparative genomic hybridization (CGH) and multicolor-FISH (M-FISH) in combination with G-banding and analysis by chromosome- and locus-specific fluorescent in situ probes to examine in detail the karyotypic characteristics of 22 lipomatous tumors, most of them classified histologically as well-differentiated liposarcomas, selected because they had been shown to harbor rings and/or marker chromosomes. M-FISH, in contrast to G- banding, was found to be informative with regard to the chromosomal origin of the rings and other markers present, whereas CGH and hybridizations with locus-specific probes helped identify which subchromosomal regions were involved. We found that chromosome bands 12q15→q21 were always gained, with 12q15→q21 being amplified (i.e., a green-to-red ratio >2 by CGH) in 14 of 22 tumors. In three tumors, two distinct but close amplicons in 12q could be identified, corresponding to bands 12q13→q15 and 12q21. The genomic segment 1q21→q23 was gained in 12 cases, reaching the level of amplification in seven. Bands 6q24 and 7p15, whose pathogenetic involvement in liposarcomas has not been reported previously, were gained in three cases each. In addition, the rings and giant markers often contained interspersed sequences from several other chromosomes that did not give an equally clear impression of being nonrandomly involved." @default.
- W1984786163 created "2016-06-24" @default.
- W1984786163 creator A5001359392 @default.
- W1984786163 creator A5001842420 @default.
- W1984786163 creator A5036087034 @default.
- W1984786163 creator A5047343715 @default.
- W1984786163 date "2002-01-01" @default.
- W1984786163 modified "2023-10-10" @default.
- W1984786163 title "Characterization of supernumerary rings and giant marker chromosomes in well-differentiated lipomatous tumors by a combination of G-banding, CGH, M-FISH, and chromosome- and locus-specific FISH" @default.
- W1984786163 cites W1484187172 @default.
- W1984786163 cites W1914118339 @default.
- W1984786163 cites W1968046362 @default.
- W1984786163 cites W1987425587 @default.
- W1984786163 cites W2034292565 @default.
- W1984786163 cites W2037479635 @default.
- W1984786163 cites W2040316588 @default.
- W1984786163 cites W2047553743 @default.
- W1984786163 cites W2069228338 @default.
- W1984786163 cites W2069644796 @default.
- W1984786163 cites W2072066791 @default.
- W1984786163 cites W2075206831 @default.
- W1984786163 cites W2083980193 @default.
- W1984786163 cites W2089726103 @default.
- W1984786163 cites W2091562621 @default.
- W1984786163 cites W2095715463 @default.
- W1984786163 cites W2110990782 @default.
- W1984786163 cites W2170828133 @default.
- W1984786163 cites W2339359539 @default.
- W1984786163 doi "https://doi.org/10.1159/000064038" @default.
- W1984786163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12438732" @default.
- W1984786163 hasPublicationYear "2002" @default.
- W1984786163 type Work @default.
- W1984786163 sameAs 1984786163 @default.
- W1984786163 citedByCount "44" @default.
- W1984786163 countsByYear W19847861632012 @default.
- W1984786163 countsByYear W19847861632015 @default.
- W1984786163 countsByYear W19847861632016 @default.
- W1984786163 countsByYear W19847861632017 @default.
- W1984786163 countsByYear W19847861632019 @default.
- W1984786163 countsByYear W19847861632020 @default.
- W1984786163 countsByYear W19847861632021 @default.
- W1984786163 countsByYear W19847861632022 @default.
- W1984786163 countsByYear W19847861632023 @default.
- W1984786163 crossrefType "journal-article" @default.
- W1984786163 hasAuthorship W1984786163A5001359392 @default.
- W1984786163 hasAuthorship W1984786163A5001842420 @default.
- W1984786163 hasAuthorship W1984786163A5036087034 @default.
- W1984786163 hasAuthorship W1984786163A5047343715 @default.
- W1984786163 hasConcept C104317684 @default.
- W1984786163 hasConcept C124942203 @default.
- W1984786163 hasConcept C130773972 @default.
- W1984786163 hasConcept C153911025 @default.
- W1984786163 hasConcept C174475383 @default.
- W1984786163 hasConcept C2777542201 @default.
- W1984786163 hasConcept C2781034694 @default.
- W1984786163 hasConcept C30481170 @default.
- W1984786163 hasConcept C4169854 @default.
- W1984786163 hasConcept C53226629 @default.
- W1984786163 hasConcept C54355233 @default.
- W1984786163 hasConcept C84597430 @default.
- W1984786163 hasConcept C86803240 @default.
- W1984786163 hasConceptScore W1984786163C104317684 @default.
- W1984786163 hasConceptScore W1984786163C124942203 @default.
- W1984786163 hasConceptScore W1984786163C130773972 @default.
- W1984786163 hasConceptScore W1984786163C153911025 @default.
- W1984786163 hasConceptScore W1984786163C174475383 @default.
- W1984786163 hasConceptScore W1984786163C2777542201 @default.
- W1984786163 hasConceptScore W1984786163C2781034694 @default.
- W1984786163 hasConceptScore W1984786163C30481170 @default.
- W1984786163 hasConceptScore W1984786163C4169854 @default.
- W1984786163 hasConceptScore W1984786163C53226629 @default.
- W1984786163 hasConceptScore W1984786163C54355233 @default.
- W1984786163 hasConceptScore W1984786163C84597430 @default.
- W1984786163 hasConceptScore W1984786163C86803240 @default.
- W1984786163 hasIssue "1-2" @default.
- W1984786163 hasLocation W19847861631 @default.
- W1984786163 hasLocation W19847861632 @default.
- W1984786163 hasOpenAccess W1984786163 @default.
- W1984786163 hasPrimaryLocation W19847861631 @default.
- W1984786163 hasRelatedWork W119049674 @default.
- W1984786163 hasRelatedWork W1968257012 @default.
- W1984786163 hasRelatedWork W2029781051 @default.
- W1984786163 hasRelatedWork W2039323378 @default.
- W1984786163 hasRelatedWork W2057981544 @default.
- W1984786163 hasRelatedWork W2086777006 @default.
- W1984786163 hasRelatedWork W2094525574 @default.
- W1984786163 hasRelatedWork W2114371511 @default.
- W1984786163 hasRelatedWork W2135187220 @default.
- W1984786163 hasRelatedWork W2407885990 @default.
- W1984786163 hasVolume "97" @default.
- W1984786163 isParatext "false" @default.
- W1984786163 isRetracted "false" @default.
- W1984786163 magId "1984786163" @default.
- W1984786163 workType "article" @default.