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• W1984788897 endingPage "1988" @default.
• W1984788897 startingPage "1975" @default.
• W1984788897 abstract "Peripheral nerve regeneration within guidance conduits involves a critical association between regenerating axons, Schwann cells (SCs), and neovascularization. However, it is currently unknown if there is a greater association between these factors in nonpermeable versus semipermeable nerve guide conduits. We therefore examined this collaboration in both silicone- and collagen-based nerve conduits in both 5- and 10-mm-injury gaps in rat sciatic nerves. Results indicate that collagen conduits promoted enhanced axonal and SC regeneration and association when compared to silicone conduits in the shorter 5-mm-gap model. In addition, collagen tubes displayed enhanced neovascularization over silicone conduits, suggesting that these three factors are intimately related in successful peripheral nerve regeneration. At later time points (1- and 2-month analysis) in a 10-mm-gap model, collagen tubes displayed enhanced axonal regeneration, myelination, and vascularization when compared to silicone-based conduits. Results from these studies suggest that regenerating cables within collagen-based conduits are revascularized earlier and more completely, which in turn enhances peripheral nerve regeneration through these nerve guides as compared to silicone conduits." @default.
• W1984788897 created "2016-06-24" @default.
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• W1984788897 date "2009-08-01" @default.
• W1984788897 modified "2023-10-02" @default.
• W1984788897 title "Collagen Nerve Conduits Promote Enhanced Axonal Regeneration, Schwann Cell Association, and Neovascularization Compared to Silicone Conduits" @default.
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• W1984788897 doi "https://doi.org/10.1089/ten.tea.2008.0338" @default.
• W1984788897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19196132" @default.
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