Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984789764> ?p ?o ?g. }
- W1984789764 endingPage "645" @default.
- W1984789764 startingPage "640" @default.
- W1984789764 abstract "Silent infarcts have been reported in 17% of young patients with sickle cell disease and are associated with impaired performance on standardized psychometric tests. Risk factors for the development of these lesions have not been identified.Investigators in the Cooperative Study of Sickle Cell Disease performed a brain magnetic resonance imaging scan on sickle cell anemia patients age 5.9 years and older who had been followed according to the protocols of the Cooperative Study since birth. Individuals with a known history of cerebrovascular accident were excluded from this analysis. Patients with and without silent infarctions were compared with regard to clinical and laboratory parameters.The study sample included 42 patients (18.3%) with silent infarcts. Patients who had silent infarcts were significantly more likely to have a clinical history of seizure and a lower painful event rate. Lower hemoglobin level, increased leukocyte count, elevated pocked red blood cell count, and SEN betaS globin gene haplotype were associated also with the presence of silent infarcts. There was no relationship between silent infarcts and platelet count, fetal hemoglobin level, reticulocyte percentage, serum aspartate aminotransferase level, total bilirubin concentration, blood pressure, growth parameters, or presence of alpha-thalassemia. A multivariate model for silent infarction identified the following as risk factors: low pain event rate, history of seizure, leukocyte count >/=11.8 x 10(9)/L, and the SEN betaS globin gene haplotype.Patients with risk factors for silent infarcts should be evaluated for cerebrovascular disease. If evidence of infarction is found, consideration must be given to therapeutic intervention. At present, the appropriate treatment has not been determined." @default.
- W1984789764 created "2016-06-24" @default.
- W1984789764 creator A5000138899 @default.
- W1984789764 creator A5015687029 @default.
- W1984789764 creator A5016291356 @default.
- W1984789764 creator A5024752787 @default.
- W1984789764 creator A5027841099 @default.
- W1984789764 creator A5036043543 @default.
- W1984789764 creator A5036676057 @default.
- W1984789764 creator A5044827789 @default.
- W1984789764 creator A5047418153 @default.
- W1984789764 creator A5048907582 @default.
- W1984789764 creator A5056946591 @default.
- W1984789764 creator A5068017197 @default.
- W1984789764 creator A5068998171 @default.
- W1984789764 creator A5087371438 @default.
- W1984789764 date "1999-03-01" @default.
- W1984789764 modified "2023-10-05" @default.
- W1984789764 title "Silent Cerebral Infarcts in Sickle Cell Anemia: A Risk Factor Analysis" @default.
- W1984789764 cites W1488638920 @default.
- W1984789764 cites W1513759151 @default.
- W1984789764 cites W1597151660 @default.
- W1984789764 cites W1608551040 @default.
- W1984789764 cites W1619099205 @default.
- W1984789764 cites W1673622155 @default.
- W1984789764 cites W1992575642 @default.
- W1984789764 cites W200707284 @default.
- W1984789764 cites W2007657412 @default.
- W1984789764 cites W2019805036 @default.
- W1984789764 cites W2031113061 @default.
- W1984789764 cites W2039678166 @default.
- W1984789764 cites W2055817154 @default.
- W1984789764 cites W2079173342 @default.
- W1984789764 cites W2102052544 @default.
- W1984789764 cites W2127456885 @default.
- W1984789764 cites W2137512897 @default.
- W1984789764 cites W2267505671 @default.
- W1984789764 cites W2322074970 @default.
- W1984789764 cites W2323003522 @default.
- W1984789764 cites W2324143840 @default.
- W1984789764 cites W2334263927 @default.
- W1984789764 cites W2338865912 @default.
- W1984789764 cites W2412227310 @default.
- W1984789764 cites W63041568 @default.
- W1984789764 cites W2314213298 @default.
- W1984789764 doi "https://doi.org/10.1542/peds.103.3.640" @default.
- W1984789764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10049969" @default.
- W1984789764 hasPublicationYear "1999" @default.
- W1984789764 type Work @default.
- W1984789764 sameAs 1984789764 @default.
- W1984789764 citedByCount "279" @default.
- W1984789764 countsByYear W19847897642012 @default.
- W1984789764 countsByYear W19847897642013 @default.
- W1984789764 countsByYear W19847897642014 @default.
- W1984789764 countsByYear W19847897642015 @default.
- W1984789764 countsByYear W19847897642016 @default.
- W1984789764 countsByYear W19847897642017 @default.
- W1984789764 countsByYear W19847897642018 @default.
- W1984789764 countsByYear W19847897642019 @default.
- W1984789764 countsByYear W19847897642020 @default.
- W1984789764 countsByYear W19847897642021 @default.
- W1984789764 countsByYear W19847897642022 @default.
- W1984789764 countsByYear W19847897642023 @default.
- W1984789764 crossrefType "journal-article" @default.
- W1984789764 hasAuthorship W1984789764A5000138899 @default.
- W1984789764 hasAuthorship W1984789764A5015687029 @default.
- W1984789764 hasAuthorship W1984789764A5016291356 @default.
- W1984789764 hasAuthorship W1984789764A5024752787 @default.
- W1984789764 hasAuthorship W1984789764A5027841099 @default.
- W1984789764 hasAuthorship W1984789764A5036043543 @default.
- W1984789764 hasAuthorship W1984789764A5036676057 @default.
- W1984789764 hasAuthorship W1984789764A5044827789 @default.
- W1984789764 hasAuthorship W1984789764A5047418153 @default.
- W1984789764 hasAuthorship W1984789764A5048907582 @default.
- W1984789764 hasAuthorship W1984789764A5056946591 @default.
- W1984789764 hasAuthorship W1984789764A5068017197 @default.
- W1984789764 hasAuthorship W1984789764A5068998171 @default.
- W1984789764 hasAuthorship W1984789764A5087371438 @default.
- W1984789764 hasConcept C126322002 @default.
- W1984789764 hasConcept C164705383 @default.
- W1984789764 hasConcept C172680121 @default.
- W1984789764 hasConcept C2776317666 @default.
- W1984789764 hasConcept C2777798775 @default.
- W1984789764 hasConcept C2778248108 @default.
- W1984789764 hasConcept C2778620579 @default.
- W1984789764 hasConcept C2779134260 @default.
- W1984789764 hasConcept C2779234561 @default.
- W1984789764 hasConcept C500558357 @default.
- W1984789764 hasConcept C50440223 @default.
- W1984789764 hasConcept C54355233 @default.
- W1984789764 hasConcept C71924100 @default.
- W1984789764 hasConcept C86803240 @default.
- W1984789764 hasConcept C90924648 @default.
- W1984789764 hasConceptScore W1984789764C126322002 @default.
- W1984789764 hasConceptScore W1984789764C164705383 @default.
- W1984789764 hasConceptScore W1984789764C172680121 @default.
- W1984789764 hasConceptScore W1984789764C2776317666 @default.
- W1984789764 hasConceptScore W1984789764C2777798775 @default.