FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984791395> ?p ?o ?g. }

• W1984791395 endingPage "569" @default.
• W1984791395 startingPage "565" @default.
• W1984791395 abstract "The aim of this study was to evaluate the effect of epinephrine as additive for propranolol as an infiltrative anesthetic. Using a rat model of cutaneous trunci muscle reflex (CTMR), we tested the effect of co-administration of epinephrine with propranolol on infiltrative cutaneous analgesia. Bupivacaine, a long-lasting local anesthetic, was used as control. Subcutaneous propranolol and bupivacaine elicited a dose-dependent local anesthetic effect on infiltrative cutaneous analgesia. On the 50% effective dose (ED50) basis, the relative potency was bupivacaine [2.05 (1.95–2.21) μmol/kg]>propranolol [9.21 (9.08–9.42) μmol/kg] (P<0.01 for each comparison). Subcutaneous epinephrine (0.012 μmol/kg) did not produce cutaneous analgesia. Mixtures of epinephrine (0.012 μmol/kg) with drugs (propranolol or bupivacaine) at ED50 or ED95, respectively, intensified and prolonged drug action on infiltrative cutaneous analgesia. Intraperitoneal injection of combined drugs (propranolol or bupivacaine) at ED95 with epinephrine (0.012 μmol/kg) exhibited no cutaneous analgesia. We concluded that propranolol was less potent but produced a similar duration of action when compared to bupivacaine on infiltrative cutaneous analgesia. Epinephrine as adjuvant for propranolol or bupivacaine enhanced the potency and extended the duration of action on infiltrative cutaneous analgesia." @default.
• W1984791395 created "2016-06-24" @default.
• W1984791395 creator A5000636156 @default.
• W1984791395 creator A5008680869 @default.
• W1984791395 creator A5032122455 @default.
• W1984791395 creator A5046663995 @default.
• W1984791395 creator A5068209077 @default.
• W1984791395 creator A5081945129 @default.
• W1984791395 date "2014-10-01" @default.
• W1984791395 modified "2023-09-25" @default.
• W1984791395 title "Epinephrine as adjuvant for propranolol produces a marked peripheral action in intensifying and prolonging analgesia in response to local dorsal cutaneous noxious pinprick in rats" @default.
• W1984791395 cites W1906794920 @default.
• W1984791395 cites W1963910752 @default.
• W1984791395 cites W1977953535 @default.
• W1984791395 cites W1978352694 @default.
• W1984791395 cites W1983274657 @default.
• W1984791395 cites W1996971698 @default.
• W1984791395 cites W1997126195 @default.
• W1984791395 cites W2006139847 @default.
• W1984791395 cites W2010974371 @default.
• W1984791395 cites W2013821838 @default.
• W1984791395 cites W2017100819 @default.
• W1984791395 cites W2020633895 @default.
• W1984791395 cites W2022678533 @default.
• W1984791395 cites W2026263347 @default.
• W1984791395 cites W2036839837 @default.
• W1984791395 cites W2039939113 @default.
• W1984791395 cites W2040102707 @default.
• W1984791395 cites W2042889512 @default.
• W1984791395 cites W2046425717 @default.
• W1984791395 cites W2047770473 @default.
• W1984791395 cites W2050639128 @default.
• W1984791395 cites W2055513620 @default.
• W1984791395 cites W2063212852 @default.
• W1984791395 cites W2065869680 @default.
• W1984791395 cites W2073926673 @default.
• W1984791395 cites W2076474825 @default.
• W1984791395 cites W2078317748 @default.
• W1984791395 cites W2087454739 @default.
• W1984791395 cites W2090982694 @default.
• W1984791395 cites W2093669420 @default.
• W1984791395 cites W2121200871 @default.
• W1984791395 cites W2129480849 @default.
• W1984791395 cites W2146329936 @default.
• W1984791395 cites W2151990704 @default.
• W1984791395 cites W2169054045 @default.
• W1984791395 cites W2327477462 @default.
• W1984791395 cites W2465771345 @default.
• W1984791395 cites W4238324778 @default.
• W1984791395 cites W4245985905 @default.
• W1984791395 cites W85121638 @default.
• W1984791395 doi "https://doi.org/10.1016/j.ejphar.2014.06.029" @default.
• W1984791395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24973696" @default.
• W1984791395 hasPublicationYear "2014" @default.
• W1984791395 type Work @default.
• W1984791395 sameAs 1984791395 @default.
• W1984791395 citedByCount "12" @default.
• W1984791395 countsByYear W19847913952015 @default.
• W1984791395 countsByYear W19847913952016 @default.
• W1984791395 countsByYear W19847913952017 @default.
• W1984791395 countsByYear W19847913952018 @default.
• W1984791395 countsByYear W19847913952019 @default.
• W1984791395 countsByYear W19847913952022 @default.
• W1984791395 crossrefType "journal-article" @default.
• W1984791395 hasAuthorship W1984791395A5000636156 @default.
• W1984791395 hasAuthorship W1984791395A5008680869 @default.
• W1984791395 hasAuthorship W1984791395A5032122455 @default.
• W1984791395 hasAuthorship W1984791395A5046663995 @default.
• W1984791395 hasAuthorship W1984791395A5068209077 @default.
• W1984791395 hasAuthorship W1984791395A5081945129 @default.
• W1984791395 hasConcept C126322002 @default.
• W1984791395 hasConcept C126838900 @default.
• W1984791395 hasConcept C149857219 @default.
• W1984791395 hasConcept C170493617 @default.
• W1984791395 hasConcept C185592680 @default.
• W1984791395 hasConcept C202751555 @default.
• W1984791395 hasConcept C2775859304 @default.
• W1984791395 hasConcept C2778151854 @default.
• W1984791395 hasConcept C2778994108 @default.
• W1984791395 hasConcept C2781328992 @default.
• W1984791395 hasConcept C42219234 @default.
• W1984791395 hasConcept C42533223 @default.
• W1984791395 hasConcept C55493867 @default.
• W1984791395 hasConcept C57992300 @default.
• W1984791395 hasConcept C71924100 @default.
• W1984791395 hasConcept C98274493 @default.
• W1984791395 hasConceptScore W1984791395C126322002 @default.
• W1984791395 hasConceptScore W1984791395C126838900 @default.
• W1984791395 hasConceptScore W1984791395C149857219 @default.
• W1984791395 hasConceptScore W1984791395C170493617 @default.
• W1984791395 hasConceptScore W1984791395C185592680 @default.
• W1984791395 hasConceptScore W1984791395C202751555 @default.
• W1984791395 hasConceptScore W1984791395C2775859304 @default.
• W1984791395 hasConceptScore W1984791395C2778151854 @default.
• W1984791395 hasConceptScore W1984791395C2778994108 @default.
• W1984791395 hasConceptScore W1984791395C2781328992 @default.
• W1984791395 hasConceptScore W1984791395C42219234 @default.
• W1984791395 hasConceptScore W1984791395C42533223 @default.

• next