FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984799329> ?p ?o ?g. }

• W1984799329 endingPage "150" @default.
• W1984799329 startingPage "139" @default.
• W1984799329 abstract "The concurrent use of cocaine and opiate combinations (speedball) has increased since the 1970s and now represents a growing subset of intravenous drug abusers. An isobolographic analysis was applied to the ascending limb of the dose–effect curves for rat self-administration of cocaine, heroin, and their combination to determine the nature of the interaction. The addition of heroin to cocaine shifted the dose–effect curve for self-administration to the left, and the modulation in reinforcing efficacy of the combination of cocaine and heroin was found to be additive. A second experiment used microdialysis to determine the effects of this drug combination on nucleus accumbens (NAc) extracellular levels of dopamine ([DA]e) in rats self-administering low doses of cocaine, heroin, or cocaine/heroin combinations. These doses of cocaine and cocaine/heroin combinations significantly increased NAc [DA]e, while heroin alone did not. The ratio of the % baseline of [DA]e (or the dialysate concentrations of DA) to cocaine in the dialysate was higher during self-administration of cocaine/heroin combinations than with cocaine alone. These data indicate that although the interaction between cocaine and heroin in maintaining self-administration is additive, a potentiation of NAc dopaminergic neurotransmission is present, suggesting that NAc [DA]e may not be a direct measure of reinforcing efficacy and/or it is not central to the mediation of the self-administration of this drug combination." @default.
• W1984799329 created "2016-06-24" @default.
• W1984799329 creator A5005739875 @default.
• W1984799329 creator A5070425865 @default.
• W1984799329 creator A5070480193 @default.
• W1984799329 creator A5075062768 @default.
• W1984799329 creator A5088211756 @default.
• W1984799329 date "2005-06-01" @default.
• W1984799329 modified "2023-10-02" @default.
• W1984799329 title "Self-Administered Heroin and Cocaine Combinations in the Rat: Additive Reinforcing Effects—Supra-Additive Effects on Nucleus Accumbens Extracellular Dopamine" @default.
• W1984799329 cites W1523806406 @default.
• W1984799329 cites W1566858817 @default.
• W1984799329 cites W1608074109 @default.
• W1984799329 cites W1777158423 @default.
• W1984799329 cites W1867412696 @default.
• W1984799329 cites W1894676325 @default.
• W1984799329 cites W1935485919 @default.
• W1984799329 cites W1938167267 @default.
• W1984799329 cites W1947372219 @default.
• W1984799329 cites W1964510410 @default.
• W1984799329 cites W1965346383 @default.
• W1984799329 cites W1967987600 @default.
• W1984799329 cites W1969016362 @default.
• W1984799329 cites W1969337660 @default.
• W1984799329 cites W1972505350 @default.
• W1984799329 cites W1974435649 @default.
• W1984799329 cites W1976722832 @default.
• W1984799329 cites W1978361913 @default.
• W1984799329 cites W1985958373 @default.
• W1984799329 cites W1986084600 @default.
• W1984799329 cites W1988380461 @default.
• W1984799329 cites W1991173233 @default.
• W1984799329 cites W1996515732 @default.
• W1984799329 cites W1999726859 @default.
• W1984799329 cites W2008003008 @default.
• W1984799329 cites W2010439035 @default.
• W1984799329 cites W2011645297 @default.
• W1984799329 cites W2013567887 @default.
• W1984799329 cites W2015825603 @default.
• W1984799329 cites W2015995696 @default.
• W1984799329 cites W2018069791 @default.
• W1984799329 cites W2020291109 @default.
• W1984799329 cites W2023190048 @default.
• W1984799329 cites W2023837052 @default.
• W1984799329 cites W2026420509 @default.
• W1984799329 cites W2026509713 @default.
• W1984799329 cites W2031975832 @default.
• W1984799329 cites W2032911818 @default.
• W1984799329 cites W2033990205 @default.
• W1984799329 cites W2036993415 @default.
• W1984799329 cites W2041359669 @default.
• W1984799329 cites W2041405553 @default.
• W1984799329 cites W2049796721 @default.
• W1984799329 cites W2050991019 @default.
• W1984799329 cites W2054580849 @default.
• W1984799329 cites W2061161259 @default.
• W1984799329 cites W2061755970 @default.
• W1984799329 cites W2068763757 @default.
• W1984799329 cites W2073346596 @default.
• W1984799329 cites W2075045365 @default.
• W1984799329 cites W2077150252 @default.
• W1984799329 cites W2077984604 @default.
• W1984799329 cites W2079288514 @default.
• W1984799329 cites W2084024177 @default.
• W1984799329 cites W2084757489 @default.
• W1984799329 cites W2088706561 @default.
• W1984799329 cites W2091339795 @default.
• W1984799329 cites W2091553801 @default.
• W1984799329 cites W2092825522 @default.
• W1984799329 cites W2094620626 @default.
• W1984799329 cites W2108098398 @default.
• W1984799329 cites W2114325644 @default.
• W1984799329 cites W2133120005 @default.
• W1984799329 cites W2139547655 @default.
• W1984799329 cites W2144693928 @default.
• W1984799329 cites W2149735042 @default.
• W1984799329 cites W2150173086 @default.
• W1984799329 cites W2154943713 @default.
• W1984799329 cites W2157663001 @default.
• W1984799329 cites W2165398609 @default.
• W1984799329 cites W2167359219 @default.
• W1984799329 cites W2210330010 @default.
• W1984799329 cites W2211403074 @default.
• W1984799329 cites W2261650087 @default.
• W1984799329 cites W2287012442 @default.
• W1984799329 cites W2299175988 @default.
• W1984799329 cites W2410258734 @default.
• W1984799329 cites W2439850763 @default.
• W1984799329 cites W2499356033 @default.
• W1984799329 cites W4232088111 @default.
• W1984799329 cites W4254322382 @default.
• W1984799329 cites W79453320 @default.
• W1984799329 doi "https://doi.org/10.1038/sj.npp.1300786" @default.
• W1984799329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4048550" @default.
• W1984799329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15956989" @default.
• W1984799329 hasPublicationYear "2005" @default.
• W1984799329 type Work @default.
• W1984799329 sameAs 1984799329 @default.

• next