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- W1984804470 endingPage "3079" @default.
- W1984804470 startingPage "3069" @default.
- W1984804470 abstract "Whereas research on CD1d has emphasized a few glycosyl ceramides, the broader family of four human CD1 antigen-presenting molecules binds hundreds of distinct self-lipids. Individual lipid types bind within CD1 grooves in different ways, such that they partially fill the groove, match the groove volume, or protrude substantially from the groove. These differing modes of binding can now be connected to differing immunological functions, as individual lipids can act as stimulatory antigens, inhibitory ligands, or space-filling scaffolds. Because each type of CD1 protein folds to produce antigen-binding grooves with differing sizes and shapes, CD1a, CD1b, CD1c, CD1d, and CD1e have distinct mechanisms of capturing self-lipids and exchanging them for foreign lipids. The size discrepancy between endogeneous lipids and groove volume is most pronounced for CD1b. Recent studies show that the large CD1b cavity can simultaneously bind two self-lipids, the antigen, and its scaffold lipid, which can be exchanged for one large bacterial lipid. In this review, we will highlight recent studies showing how cells regulate lipid antigen loading and the roles CD1 groove structures have in control of the presentation of chemically diverse lipids to T cells." @default.
- W1984804470 created "2016-06-24" @default.
- W1984804470 creator A5017527950 @default.
- W1984804470 creator A5074940171 @default.
- W1984804470 date "2014-03-23" @default.
- W1984804470 modified "2023-10-16" @default.
- W1984804470 title "The CD1 size problem: lipid antigens, ligands, and scaffolds" @default.
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- W1984804470 doi "https://doi.org/10.1007/s00018-014-1603-6" @default.
- W1984804470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4160407" @default.
- W1984804470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24658584" @default.
- W1984804470 hasPublicationYear "2014" @default.