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• W1984807625 abstract "Adeno-associated viruses are being developed as vectors for gene therapy and have been used in a number of clinical trials. Vectors to date have been based on the type species AAV-2, the structure of which was published in 2002. There is growing interest in modulating the cellular tropism and immune neutralization of AAV-2 with variants inspired by the properties of other serotypes. Towards the determination of a structure for AAV type 6, this paper reports the high-yield production, purification, crystallization and preliminary diffraction studies of infectious AAV-6 virions. The crystals diffracted to 3.2 Å resolution using synchrotron radiation. The most promising crystal form belonged to space group R3 and appeared to be suitable for initial structure determination." @default.
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• W1984807625 date "2008-10-31" @default.
• W1984807625 modified "2023-09-27" @default.
• W1984807625 title "Crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 6" @default.
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• W1984807625 doi "https://doi.org/10.1107/s1744309108033290" @default.
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