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• W1984809361 abstract "Fourteen different ligands have been synthesized with two covalently linked 8-hydroxyquinoline motifs that favor metal complexation. These bis-chelators include different bridges at the C2 positions and different substituents to modulate their physicochemical properties. They can form metal complexes in a ratio of one ligand per metal ion with CuII and ZnII, two metal ions involved in the formation of amyloid aggregates of the toxic Aβ-peptides in the Alzheimer disease. The apparent affinity of all bis-8-hydroxyquinoline ligands for CuII and ZnII are similar with logK ≈16 and logK ≈13 and are 10 000 times more efficient than for the corresponding 8-hydroxyquinoline monomers. Their strong chelating capacities allow them to inhibit more efficiently than the corresponding monomers the precipitation of Aβ-peptides induced by CuII and ZnII and also to inhibit the toxic formation of H2O2 due to copper complexes of Aβ. The best results were obtained with a one-atom linker between the two quinoline units. X-ray analyses of single-crystals of CuII, ZnII or NiII complexes of 2,2′-(2,2-propanediyl)-bis(8-hydroxyquinoline), including a one-atom linker, showed that all heteroatoms of the bis-8-hydroxyquinoline ligand chelate the same metal ion in a distorted square-planar geometry. The CuII and ZnII complexes include a fifth axial ligand and are pentacoordinated." @default.
• W1984809361 created "2016-06-24" @default.
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• W1984809361 date "2008-01-07" @default.
• W1984809361 modified "2023-10-16" @default.
• W1984809361 title "Preparation and Study of New Poly-8-Hydroxyquinoline Chelators for an anti-Alzheimer Strategy" @default.
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• W1984809361 doi "https://doi.org/10.1002/chem.200701024" @default.
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