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- W1984818627 abstract "Previous in vitro studies have yielded conflicting results concerning the physiological effects of alpha-bungarotoxin (alpha-BTX) at avian autonomic ganglia. In the present study heart rate change was classically conditioned in pigeons immobilized with alpha-BTX to assess the effects of this agent on autonomic function in the intact animal. When compared with non-immobilized controls, alpha-BTX had no significant effect on basal heart rate or on the rate of acquisition, magnitude or dynamics of conditioned heart rate change. Furthermore, a significant difference in performance between groups receiving conditioning and sensitization paradigms clearly indicated the establishment of conditioned responding. It is concluded that alpha-BTX has little or no effect on the cardiac innervation at doses sufficient to block neuromuscular transmission. The irreversible blockade of neuromuscular transmission by alpha-BTX without the side-effects produced by most other paralytics makes it an ideal choice as an immobilizing agent in acute preparations." @default.
- W1984818627 created "2016-06-24" @default.
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- W1984818627 date "1981-07-01" @default.
- W1984818627 modified "2023-09-24" @default.
- W1984818627 title "Heart rate conditioning in the pigeon immobilized with α-bungarotoxin" @default.
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- W1984818627 doi "https://doi.org/10.1016/0006-8993(81)91284-1" @default.
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