Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984820123> ?p ?o ?g. }
- W1984820123 endingPage "12374" @default.
- W1984820123 startingPage "12362" @default.
- W1984820123 abstract "The Epstein-Barr virus immediate-early protein, BZLF1 (Z), initiates the switch between latent and lytic infection and plays an essential role in mediating viral replication. Z also inhibits expression of the major receptor for tumor necrosis factor (TNF), TNFR1, thus repressing TNF cytokine signaling, but the mechanism for this effect is unknown. Here, we demonstrate that Z prevents both C/EBPα- and C/EBPβ-mediated activation of the TNFR1 promoter (TNFR1p) by interacting directly with both C/EBP family members. We show that Z interacts directly with C/EBPα and C/EBPβ in vivo and that a Z mutant altered at alanine residue 204 in the bZIP domain is impaired for the ability to interact with both C/EBP proteins. Furthermore, we find that the Z(A204D) mutant is attenuated in the ability to inhibit the TNFR1p but mediates lytic viral reactivation and replication in vitro in 293 cells as well as wild-type Z. Although Z does not bind directly to the TNFR1p in EMSA studies, chromatin immunoprecipitation studies indicate that Z is complexed with this promoter in vivo. The Z(A204D) mutant has reduced interaction with the TNFR1p in vivo but is similar to wild-type Z in its ability to complex with the IL-8 promoter. Finally, we show that the effect of Z on C/EBPα- and C/EBPβ-mediated activation is promoter dependent. These results indicate that Z modulates the effects of C/EBPα and C/EBPβ in a promoter-specific manner and that in some cases (including that of the TNFR1p), Z inhibits C/EBPα- and C/EBPβ-mediated activation." @default.
- W1984820123 created "2016-06-24" @default.
- W1984820123 creator A5012636364 @default.
- W1984820123 creator A5028943143 @default.
- W1984820123 creator A5069667474 @default.
- W1984820123 creator A5082636703 @default.
- W1984820123 date "2010-12-01" @default.
- W1984820123 modified "2023-09-23" @default.
- W1984820123 title "The Epstein-Barr Virus BZLF1 Protein Inhibits Tumor Necrosis Factor Receptor 1 Expression through Effects on Cellular C/EBP Proteins" @default.
- W1984820123 cites W1540516857 @default.
- W1984820123 cites W1636660170 @default.
- W1984820123 cites W1749209363 @default.
- W1984820123 cites W1768619516 @default.
- W1984820123 cites W1796088623 @default.
- W1984820123 cites W179818011 @default.
- W1984820123 cites W1801060758 @default.
- W1984820123 cites W1823218897 @default.
- W1984820123 cites W1841083068 @default.
- W1984820123 cites W1891793539 @default.
- W1984820123 cites W1947316420 @default.
- W1984820123 cites W1955814132 @default.
- W1984820123 cites W1964269036 @default.
- W1984820123 cites W1965541545 @default.
- W1984820123 cites W1981785841 @default.
- W1984820123 cites W1984652061 @default.
- W1984820123 cites W1998742383 @default.
- W1984820123 cites W1999109761 @default.
- W1984820123 cites W2002707039 @default.
- W1984820123 cites W2007570855 @default.
- W1984820123 cites W2016462211 @default.
- W1984820123 cites W2017086224 @default.
- W1984820123 cites W2029101025 @default.
- W1984820123 cites W2047776784 @default.
- W1984820123 cites W2048675234 @default.
- W1984820123 cites W2048789360 @default.
- W1984820123 cites W2052516925 @default.
- W1984820123 cites W2054961298 @default.
- W1984820123 cites W2055736709 @default.
- W1984820123 cites W2057749060 @default.
- W1984820123 cites W2062307277 @default.
- W1984820123 cites W2066231167 @default.
- W1984820123 cites W2069681479 @default.
- W1984820123 cites W2070193382 @default.
- W1984820123 cites W2075426776 @default.
- W1984820123 cites W2078329210 @default.
- W1984820123 cites W2078526535 @default.
- W1984820123 cites W2078562482 @default.
- W1984820123 cites W2085161568 @default.
- W1984820123 cites W2085957706 @default.
- W1984820123 cites W2090402866 @default.
- W1984820123 cites W2093799212 @default.
- W1984820123 cites W2094144752 @default.
- W1984820123 cites W2094835614 @default.
- W1984820123 cites W2097141103 @default.
- W1984820123 cites W2105526885 @default.
- W1984820123 cites W2105959269 @default.
- W1984820123 cites W2116109634 @default.
- W1984820123 cites W2119535180 @default.
- W1984820123 cites W2121749875 @default.
- W1984820123 cites W2123029438 @default.
- W1984820123 cites W2123711411 @default.
- W1984820123 cites W2124968337 @default.
- W1984820123 cites W2125037747 @default.
- W1984820123 cites W2125723193 @default.
- W1984820123 cites W2129011493 @default.
- W1984820123 cites W2129604047 @default.
- W1984820123 cites W2133726754 @default.
- W1984820123 cites W2138441377 @default.
- W1984820123 cites W2139718667 @default.
- W1984820123 cites W2142121971 @default.
- W1984820123 cites W2142234363 @default.
- W1984820123 cites W2149655243 @default.
- W1984820123 cites W2152827395 @default.
- W1984820123 cites W2159991658 @default.
- W1984820123 cites W2164313428 @default.
- W1984820123 cites W2166043441 @default.
- W1984820123 cites W2167835886 @default.
- W1984820123 cites W2171925218 @default.
- W1984820123 cites W2209450952 @default.
- W1984820123 cites W2400313130 @default.
- W1984820123 cites W4243675956 @default.
- W1984820123 cites W4243695823 @default.
- W1984820123 cites W4254849374 @default.
- W1984820123 doi "https://doi.org/10.1128/jvi.00712-10" @default.
- W1984820123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2976414" @default.
- W1984820123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20861254" @default.
- W1984820123 hasPublicationYear "2010" @default.
- W1984820123 type Work @default.
- W1984820123 sameAs 1984820123 @default.
- W1984820123 citedByCount "16" @default.
- W1984820123 countsByYear W19848201232012 @default.
- W1984820123 countsByYear W19848201232013 @default.
- W1984820123 countsByYear W19848201232014 @default.
- W1984820123 countsByYear W19848201232015 @default.
- W1984820123 countsByYear W19848201232016 @default.
- W1984820123 countsByYear W19848201232019 @default.
- W1984820123 countsByYear W19848201232020 @default.
- W1984820123 countsByYear W19848201232021 @default.